ASSOCIATE

e-mail: borgiani@uniroma2.it
Office: +39 06 7259 6028
SSD: MED/03
SC: 06/A1
Macro-area:
Genetica Medica
Research area
-Study of genetic factors and their interactions in the susceptibility to multifactorial diseases and their role in the clinical manifestations and phenotypes;
-Pharmacogenetics and Pharmacogenomics;
-Genomic Biomarkers and their application in the clinical practice. Personalized Medicine

 Prof. Paola Borgiani

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CURRICULUM VITAE

POSITON: ASSOCIATE PROFESSOR OF MEDICAL GENETICS, 
UNIVERSITY OF ROME “TOR VERGATA”

EDUCATION /TRAINING:
1980-1984: Degree in Biology, University of Camerino (Dissertation of a thesis in Human Genetics); 
1987: PhD in Clinical and Biochemical Chemistry and Microbiology, University of Camerino (Dissertation of a thesis in Biochemical Genetics).
1983-85: Training in the Lab of Genetics, University of Camerino 

PREVIOUS POSITIONS AND EMPLOYMENTS:

1985-1988: Research Assistant University of Camerino (Lab. Of Genetics), Dept Cellular Biology: Field of Study: Human Genetics

1989-2001: Assistant Professor University of Rome "Tor Vergata", School of Medicine (Pediatrics); Field of Study: Human Genetics

1st November 2001-31st October 2014: : Assistant Professor Researcher (Medical Genetics) University of Rome "Tor Vergata", School of Medicine.

1991: Visiting Researcher at the Lab. of Biochemical Genetics, Dept. Human Genetics, Children Hospital of Buffalo, Buffalo University (USA) for a collaborative project on genetic susceptibility to Diabetes and Obesity. 

June 2000: Visiting Researcher at the Experimental Medicine Unit (University of Wales, UK) for a collaborative project on genetic susceptibility of allergy and athsma).

November 2004- April 2005: Secondment at the EMEA (European Medicine Agency, now EMA) of London as “NATIONAL EXPERT” ” in Human Genetics. EMEA Safety and Efficacy of Medicine Sector, 
(Field of Pharmacogenetics, Collaborates with Pharmacogenetics Working Party)

RESEARCH AREA: 
Study of genetic factors and their interactions in the susceptibility to multifactorial diseases and their role in the clinical manifestations and phenotypes; Pharmacogenetics and Pharmacogenomics; Genomic Biomarkers and their application in the clinical practice. Personalized Medicine.
Co-author of more than 100 Papers published on “peer Reviewed” international Journal (I.F about 380; H-index 21)

2000-2015:  Unit PI of about 10 different Grants Projects at national and international level


TEACHING ACTIVITY:
Teaching Genetics, Medical Genetics, Pharmacogenomics at different courses of the Faculty of Medicine and Sciences, University of Rome, “Tor Vergata” (teaching Medical genetics at different PhD, Masters, degrees courses), also in English courses (i.e. Pharmacogenomics Couse at the European degree of Pharmacy, English degree in Medicine ). 
Tutor of about 20 thesys (Degree level, Doctorate and Specialization School and Masters)
 

MEMBER of Italian Society of Human Genetics (SIGU): member of the Pharmacogenetics Working Party.


EDITORIAL BOARD MEMBER “Biomedicine and Prevention” http://www.biomedicineandprevention.com/)
Ad Hoc Reviewer for: Pharmacogenomics, PlosOne, Pharmacogenetics and Genomics, 
Immunogenetics, Annals of Human Biology, Disease Markers, and other International Peer review Journals

Pubblicazioni rilevanti

• Borgiani P, Ciccacci C, Forte V, Sirianni E, Novelli L, Bramanti P, Novelli G. CYP4F2 genetic variant (rs2108622) significantly contributes to warfarin dosing variability in the Italian population. Pharmacogenomics. 2009 Feb;10(2):261-6. 2)
• Ciccacci C, Di Fusco D, Cacciotti L, Morganti R, D'Amato C, Novelli G, Sangiuolo F, Spallone V, Borgiani P.  TCF7L2 gene polymorphisms and type 2 diabetes: association with diabetic retinopathy and cardiovascular autonomic neuropathy.Acta Diabetol. 2012 Jul 28. 3)
• Ciccacci C, Falconi M, Paolillo N, Oteri F, Forte V, Novelli G, Desideri A, Borgiani P. Characterization of a novel CYP2C9 gene mutation and structural bioinformatic protein analysis  in a warfarin hypersensitive patient. Pharmacogenet Genomics. 2011 Jun;21(6):344-6
• Borgiani P, Ciccacci C, Forte V, Romano S, Federici G & Novelli G. Allelic variants in the CYP2C9 and VKORC1 loci and inter-individual variability in the anticoagulant dose effect of warfarin in an Italian population. Pharmacogenomics 2007 Nov;8(11):1545-50.
• Borgiani P, Perricone C, Biancone L, Romano S, Ciccacci C, Novelli G, Pallone F. The IL23R gene Arg381Gln polymorphism is associated with susceptibility to Crohn disease but not with phenotype in Italian population. Gastroenterology. 2007 Sep;133(3):1049-51