Dr. Luisa Campagnolo
Prof. Campagnolo has a broad background in reproductive and developmental biology, in histology and in vascular and stem cell biology. Research in her lab has been supported by grants from the Lazio Region, the European Community, the Italian Ministry of Health and the March of Dimes. Dr Campagnolo has served as the Italian Representative in the Management Committee of the EU COST Action MODENA TD1204 and has been recently nominated Italian Representative in the OECD Working Party on Manufactured Nanomaterials.
The main research focus in the Campagnolo’s lab is to examine the molecular mechanisms regulating mammalian embryo implantation and placental development. Over the last 10 years Dr Campagnolo has also developed a new research focus on toxicological aspects of engineered nanomaterials (ENM) and placental/fetal susceptibility, which is strictly related to her main interests. Altogether, these studies have allowed Dr Campagnolo to establish strong collaborations with national and international research groups. The laboratory of Dr. Campagnolo possesses expertise in handling and culture of pre- and post-implantation embryos, culture of stem cells of different sources (embryonic, adult, induced), in morphological, biochemical, histological and molecular biology techniques. Three main research lines are currently followed in the laboratory: 1. Examine the role of the secreted factor Egfl7 during implantation and placental development. This project is carried out in collaboration with Dr Stuhlmann at the Weill Cornell Medical College in New York and has been supported by a pilot study grant from the March of Dimes Foundation (2014-2017), of which Dr Campagnolo is a subcontractor, and the Grant for Fertility Innovation 2017, of which she is the principal investigators. 2. Investigate the role of thyroid hormone in mammalian embryo implantation. These studies are performed in collaboration with Prof Moretti (Tor Vergata), and Dr Rago of the Pertini Hospital. 3. Study the effect of maternal exposure to ENM on placental and fetal development, and on the second generation; develop in vitro tests to evaluate transplacental passage of ENM; for these studies collaborations have been established with EU and USA groups.
Positions and Employment
Other Experience and Professional Memberships
1. Ticconi C, Di Simone N, Campagnolo L, Fazleabas A. Clinical consequences of defective decidualization. Tissue Cell. 2021 Oct;72:101586.
2. Massimiani M, Salvi S, Tiralongo GM, Moresi S, Stuhlmann H, Valensise H, Lanzone A, Campagnolo L. Circulating EGFL7 distinguishes between IUGR and PE: an observational case-control study. Sci Rep. 2021 Sep 9;11(1):17919.
3. Camaioni A, Massimiani M, Lacconi V, Magrini A, Salustri A, Sotiriou GA, Singh D, Bitounis D, Bocca B, Pino A, Barone F, Prota V, Iavicoli I, Scimeca M, Bonanno E, Cassee FR, Demokritou P, Pietroiusti A, Campagnolo L. Silica encapsulation of ZnO nanoparticles reduces their toxicity for cumulus cell-oocyte-complex expansion. Part Fibre Toxicol. 2021 Sep 3;18(1):33.
4. Massimiani M, Tiralongo GM, Salvi S, Fruci S, Lacconi V, La Civita F, Mancini M, Stuhlmann H, Valensise H, Campagnolo L. Treatment of pregnancies complicated by intrauterine growth restriction with nitric oxide donors increases placental expression of Epidermal Growth Factor-Like Domain 7 and improves fetal growth: A pilot study. Transl Res. 2020 Aug 9:S1931-5244(20)30198-5.
5. Massimiani M, Lacconi V, La Civita F, Ticconi C, Rago R, Campagnolo L. Molecular Signaling Regulating Endometrium-Blastocyst Crosstalk. Int J Mol Sci. 2019 Dec 18;21(1):23.
6. Massimiani M, Lacko LA, Burke Swanson CS, Salvi S, Argueta LB, Moresi S, Ferrazzani S, Gelber SE, Baergen RN, Toschi N, Campagnolo L, Stuhlmann H. Increased circulating levels of Epidermal Growth Factor-like Domain 7 in pregnant women affected by preeclampsia. Transl Res. 2019 May;207:19-29.
7. Pietroiusti A, Vecchione L, Malvindi MA, Aru C, Massimiani M, Camaioni A, Magrini A, Bernardini R, Sabella S, Pompa PP, Campagnolo L. Relevance to investigate different stages of pregnancy to highlight toxic effects of nanoparticles: The example of silica. Toxicol Appl Pharmacol. 2018 Mar 1;342:60-68.
8. Piccirilli D, Baldini E, Massimiani M, Camaioni A, Salustri A, Bernardini R, Centanni M, Ulisse S, Moretti C, Campagnolo L. Thyroid hormone regulates protease expression and activation of Notch signaling in implantation and embryo development. J Endocrinol. 2018 Jan;236(1):1-12.