ASSOCIATO

e-mail: campagnolo@med.uniroma2.it
Telefono: +39 06 7259 6154/51 
SSD: BIO/17
SC: 05/H2 
Macro-area:
Istologia
Campi di interesse: 
06/72596154
-Meccanismi molecolari dello sviluppo placenta
-Cellule Staminali
-Nanoparticelle e embriotossicità

 Dr. Luisa Campagnolo

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CURRICULUM VITAE
 
Dr. Campagnolo has a broad background in reproductive and developmental biology, in histology and in vascular and stem cell biology. Research in her lab has been supported by grants from the European Community, the Italian Ministry of Health and the March of Dimes. Dr Campagnolo serves as the Italian Representative in the Management Committee of the EU COST Action MODENA TD1204 and has been recently nominated Italian Representative in the OECD Working Party on Manufactured Nanomaterials.
The main research focus in the Campagnolo’s lab is to examine the molecular mechanisms regulating mammalian embryo implantation and placental development. Over the last 10 years Dr Campagnolo has also developed a new research focus on toxicological aspects of engineered nanomaterials (ENM) and placental/fetal susceptibility, which is strictly related to her main interests.  Altogether, these studies has allowed Dr Campagnolo to establish strong collaborations with national and international research groups. The laboratory of Dr. Campagnolo possesses expertise in the handling and culture of pre- and post-implantation embryos, culture of stem cells of different sources (embryonic, adult, induced), morphological, biochemical, histological and molecular biology techniques. Three main research lines are currently followed in the laboratory: 1. Examine the role of the secreted factor Egfl7 during implantation and placental development.  This project is carried out in collaboration with Dr Stuhlmann at the Weill Cornell Medical College in New York, and is supported by a pilot study grant from the March of Dimes Foundation (2014-2017), of which Dr Campagnolo is a subcontractor, and the Grant for Fertility Innovation 2017, of which she is the principal investigators. 2. Investigate the role of thyroid hormone in mammalian embryo implantation. These studies are performed in collaboration with Prof Moretti (Tor Vergata), and Dr Rago of the Pertini Hospital. 3. Study the effect of maternal exposure to ENM on placental and fetal development, and on the second generation; develop in vitro tests to evaluate transplacental passage of ENM; for these studies collaborations have been established with EU and USA groups.
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Positions and Employment
1995-1999           Graduate student of Medical Embryology, Dep of Public Health and cell Biology, University of Rome “Tor Vergata”, Rome, Italy.
1999-2000           Postdoctoral fellow , Dep of Public Health and cell Biology, University of Rome “Tor Vergata”, Rome, Italy.
2000-2003           Postdoctoral fellow, Dep Cell Biology, The Scripps Research Institute, La Jolla, CA
2002-                    Assistant Professor, Department of Biomedicine and Prevention, University of Rome “Tor Vergata”, Rome, Italy.

Other Experience and Professional Memberships
2001-2014           Member, North American Vascular Biology Organization (NAVBO)
2014-                   Member, European Society of Human Reproduction and Embryology
 
2011-                   Editorial Board, International Journal of Stem Cell & Transplantation
2019-                   Associate Eidtor, Particle and Fibre Toxicology
2019-2020             Guest Editor International Journal of Molecular Sciences
2020-                     Editorial Board Life
 
2010                    Ad Hoc Reviewer, Kentucky Science & Engineering Foundation
2010                    Ad Hoc Reviewer, Medical Research Scotland
2015                    Ad Hoc Reviewer, Italian Ministry of Instruction, University and Research
2016                    Expert Reviewer, OPUS call of the National Science Centre, Poland
​2020                      Expert Reviewer, Icelandic Research Fund

Honors
2001                     “Servier New Investigator Award” 2nd Conference on Artheriosclerosis,    Thrombosis and Vascular Biology (Washington DC)
2007-present      Visiting Assistant Professor, Weill Cornell Medical College, New York, USA
2009:                   Award Best Presentation, AIPE Meeting, Rome, ITALY
2010:                   Award Best Poster,  Nanotoxicology Meeting, Edinburgh, UK.
2015                    Invited Plenary Lecturer, Karolinska Institutet, Stockholm, Sweden
2016                    Invited Speaker, Society of Toxicology Meeting 2016, New Orleans, USA
2016                    Invited Speaker, IUTOX Meeting 2016, Merida, Mexico
2016-present     Research Associate, Dept. of Chemical Engineering, University of Pretoria

Pubblicazioni rilevanti

1: Massimiani M, Tiralongo GM, Salvi S, Fruci S, Lacconi V, La Civita F, Mancini M, Stuhlmann H, Valensise H, Campagnolo L. Treatment of pregnancies complicated by intrauterine growth restriction with nitric oxide donors increases placental expression of Epidermal Growth Factor-Like Domain 7 and improves fetal growth: A pilot study. Transl Res. 2020 Aug 9:S1931-5244(20)30198-5. doi:10.1016/j.trsl.2020.08.002. Epub ahead of print. PMID: 32784003.
 
2: Massimiani M, Lacconi V, La Civita F, Ticconi C, Rago R, Campagnolo L. Molecular Signaling Regulating Endometrium-Blastocyst Crosstalk. Int J Mol Sci. 2019 Dec 18;21(1):23. doi: 10.3390/ijms21010023. PMID: 31861484; PMCID: PMC6981505.
 
3: Massimiani M, Lacko LA, Burke Swanson CS, Salvi S, Argueta LB, Moresi S, Ferrazzani S, Gelber SE, Baergen RN, Toschi N, Campagnolo L, Stuhlmann H. Increased circulating levels of Epidermal Growth Factor-like Domain 7 in pregnant women affected by preeclampsia. Transl Res. 2019 May;207:19-29. doi: 10.1016/j.trsl.2018.12.004. Epub 2018 Dec 25. PMID: 30620888; PMCID: PMC6486846.
 
4: Pietroiusti A, Vecchione L, Malvindi MA, Aru C, Massimiani M, Camaioni A, Magrini A, Bernardini R, Sabella S, Pompa PP, Campagnolo L. Relevance to investigate different stages of pregnancy to highlight toxic effects of nanoparticles: The example of silica. Toxicol Appl Pharmacol. 2018 Mar 1;342:60-68. doi: 10.1016/j.taap.2018.01.026. Epub 2018 Jan 31. PMID: 29407774.
 
5: Piccirilli D, Baldini E, Massimiani M, Camaioni A, Salustri A, Bernardini R, Centanni M, Ulisse S, Moretti C, Campagnolo L. Thyroid hormone regulates protease expression and activation of Notch signaling in implantation and embryo development. J Endocrinol. 2018 Jan;236(1):1-12. doi: 10.1530/JOE-17-0436. Epub 2017 Oct 9. PMID: 28993437.