ORDINARIO

e-mail: defelici@uniroma2.it
Telefono: +39 06 7259 6156
SSD: BIO/07
SC: 05/H2
Macro-area:
Istologia
Campi di interesse: 
- Gametogenesi
- Cellule staminali
- Biologia dello sviluppo
Laboratorio: 
Laboratory for the study of primordial germ cells

Prof. Massimo De Felici 

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CURRICULUM VITAE

NAME: Massimo DE FELICI, Ph.D.
DATE & PLACE OF BIRTH: JUNE 10, 1951, FRASCATI, ROME (Italy)
CITIZENSHIP: ITALIAN
PRESENT ADDRESS: Department of Biomedicine and Prevention, Section of Histology and Embryology, University of Rome Vergata, Rome.
e-mail:defelici@uniroma2.it
EDUCATION
July, 1970: High School Degree
February, 1976: Ph.D. (Biology Science) degree, with honours, University of Rome Sapienza
 
EMPLOYMENT & TRAINING
1974-1976: Pre-graduate student, Laboratory of Animal Radiation Biology, C.N.E.N., Casaccía, Rome
1976-1978: CNR Postdoctoral Fellow, Institute of Histology and General Embryology, Uni Rome Sapienza
1981-1982: Royal Society Fellow, MRC Mammalian Development Unit, Uni College, London
1982-1987: Researcher, Institute of Hist and Gen Embr, Uni Rome Sapienza
1987-1999: Associate Prof, Dep. Public Health, Section of Histology and Embryology, Uni Rome Tor Vergata
2000-to day: Full Prof Histology, Dep. Pub Health and Cell Biol and then Dep. of Biomed and Prevention, Uni Rome Tor Vergata
2005-2008: Vice-Director of Dep. Public Health and Cell Biol Uni Rome Tor Vergata; Member of the Committee of the Station for Animal Technologies of the Uni Rome Tor Vergata
2010-to day: Director of the Hist and Embr Section of the Faculty of Medicine, Uni Rome Tor Vergata
 
RESEARCH INTERESTS
 
Biochemical mechanisms of oocyte maturation and fertilization; Stem Cell Biology; Development and differentiation of mammalian germ cells
MEMBERSHIP OF SCIENTIFIC SOCIETIES
Italian Society of Cell Differentiation and Development; American Society for the Study of Reproduction; American Society for Developmental Biology; member of Rome Medical Academy
SCIENTIFIC ACTIVITY
-148 Full papers on International Journals; 15 Publications on National Journals or Books; 30 Chapters on International Books or in Proceedings of International Congresses; Total= 191
- H index (2017)= Scopus 44; IF > 600
- 35  National Grants; 3 International Grants (2 EU, 1 UK)
- 30 Invitations as main speaker at International Congresses; 11 invitations as main speaker at National Congresses
 
HONORS AND AWARDS
-Second Prize by ALTRAN Foundation for Innovation Award  2012 for Research Project on Stem Cell Biology
-First Prize ESHRE Research Grant 2014
-HI within 100 Top Italian Scientists
 
MEMBER OF EDITORIAL BOARD AND REVIEWER
- Member of the editorial board of: 1. International Journal of Developmental Biology, 2. The Open Reproduction Science Journal, 3. American Journal of Stem Cells, 4. Journal of Stem Cells, 5. ISRN Developmental Biology, 6. Asian Pacific Journal of Reproduction, 7. Dataset Papers in Science Molecular Biology, 8. Austin Journal of In vitro Fertilization, 9. Austin Journal of Reproductive Medicine & Infertility. 10. Biomedicine and Prevention, 11. Epigenetic Diagnosis &Therapy.
- Regular reviewer for Cell Death and Diff, Exp Cell Res, Dev Biol, Differentiation, Biology of Reproduction, Nature, PNAS, Development.
- Reviewer for Italian Ministry of Research (PRIN and VQR), Italy; International Human Frontier Science Program; National Science Foundation, USA; Lalor Foundation, USA; ICGEB Collaborative Research Programme, Italy; The French National Research Agency (ANR), France

 
Publications MDF
 
A) Publications on International Journals
 
 
1) Siracusa, G., De Felici, M., Coletta, M., and Vivarelli, E. (1978). Inhibitors of protein synthesis increase the agglutinability mediated by Concanavalin A of unfertilized mouse eggs. Dev. Biol. 62 (2),  530-533.
 
2) Siracusa, G., Whittingham, D. G., Codonesu, M., and De Felici, M. (1978). Local anesthetics and phenothiazine tranquilizers induce parthenogenetic activation of the mouse oocytes. Dev. Biol. 65, 531-535.
 
3) De Felici, M., and Siracusa, G. (1980). Changes in Concanavalin A-mediated agglutinability of mouse oocytes during meiosis. Dev. Biol. 76, 428-434.
 
4) Siracusa, G., Whittingham, D.G., and De Felici, M. (1980). The effect of microtubule and microfilaments desrupting drugs on preimplantation mouse embryos. J. Embryol. Exp. Morph. 60, 71-81.
 
5) De Felici, M., and Siracusa, G. (1981). Fertilization-induced changes in Concanavalin A binding to mouse eggs. Exp. Cell. Res. 132, 41-45.
 
6) De Felici, M., Vivarelli, E., Giustiniani, Q., and Siracusa, G. (1982). Reversible inhibition of meiosis resumption in mouse dictyate oocytes by sub-optimal media. Cell. Biol. Int. Rep. 6, 99-103.
 
7) De Felici, M., and Siracusa, G. (1982). "Spontaneous" hardening of the zona pellucida of mouse oocytes during in vitro culture. Gamete Res. 6, 107-113.
 
8) De Felici, M., and Siracusa, G. (1982). Survival of isolated, fully grown mouse ovarian oocytes is strictly dependent on external calcium. Dev. Biol. 92, 539-543.
 
9) De Felici, M., and McLaren, A. (1982). Isolation of mouse primordial germ cells. Exp. Cell. Res. 142, 476-482.
 
10) De Felici, M., and McLaren, A. (1983). In vitro culture of mouse primordial germ cells. Exp. Cell. Res. 144, 417-427.
 
11) Vivarelli, E., Conti, M., De Felici, M., and Siracusa, G. (1983). Meiotic resumption and cAMP intracellular levels in mouse oocytes treated with compounds which act on cAMP. Cell Diff. 12, 271-276.
 
12) De Felici M. (1984). Apects of germ cell differentiation in the mammalian embryo. Arch Ital Anat Embriol 89, 13-30.
 
13) De Felici, M. (1984). Binding of fluorescent lectins to the surface of germ cells from fetal and early postnatal mouse gonads. Gamete Res. 10, 423-432.
 
14) De Felici, M., Boitani, C., and Cossu, G. (1985). Synthesis of glycoconjugates in mouse primordial germ cells. Dev. Biol. 109, 375-380.
 
15) De Felici, M., and Siracusa, G. (1985). Adhesiveness of mouse primordial germ cells to follicular and Sertoli cells monolayers. J. Embryol. Exp. Morph. 87, 87-97.
 
16) De Felici, M., Salustri, A., Siracusa, G. (1985). "Spontaneous" hardening of the zona pellucida of mouse oocytes during in vitro culture. II. The effect of follicular fluid and glycosaminoglicans. Gamet. Res. 12, 227-235. 
 
17) Salustri, A., Petrungaro, S., De Felici, M., and Siracusa, G. (1985). Effect of follicle stimulating hormone on cyclic adenosine monophosphate level and on meiotic maturation in mouse cumulus cell enclosed oocytes cultured in vitro. Biol. Reprod. 33, 792-802.
 
18) De Felici, M., Eusebi, F., and Fratamico, G. (1985). Cell-to cell electrical coupling in seminiferous cords of mouse fetal testis. Cell. Biol. Int. Rep. 9, 825-832.
 
19) De Felici, M., Heasman, J., Wylie, C. C., and McLaren, A. (1986). Macrophages in the urogenital ridge of the mid-gestation mouse fetus. Cell Diff. 18, 119-129.
 
20) De Felici, M., Dolci, S. and Siracusa, G. (1987). Involvement of thiol-disulfate groups in the sensitivity of fully grown mouse oocytes to calcium-free medium. J. Exp. Zool. 243, 283-287.
 
21) De Felici, M., and Dolci, S. (1987). Cellular interactions of mouse fetal germ cells in vitro systems. Curr. Top. Dev. Biol. 23, 147-162.
 
22) Canipari, R., Bevilacqua, A., Colonna, R., De Felici, M., and Mangia, F. (1988). Actin synthesis is not regulated by granulosa cells in mouse growing and preovulatory oocytes. Gamete Res. 20, 1-10.
 
23) De Felici, M., and Dolci, S. (1989). In vitro adhesion of mouse fetal germ cells to extracellular matrix components. Cell. Diff. Dev. 26, 87-96.
 
24) De Felici, M., Dolci, S., and Siracusa, G. (1989). Influence of cumulus cell processes on oolemma permeability and lethality of isolated mouse oocytes cultured in Ca2+-free medium. Gamete Res. 23, 245-253.
 
25) De Felici, M., Dolci, S., and Siracusa, G. (1989). Fetal germ cells establish coupling with follicle cells in vitro. Cell. Diff. Dev. 28, 65-69.
 
26) Dolci, S., and De Felici, M. (1990). A study of meiosis in chimeric mouse fetal gonads. Development 109, 37-40.
 
27) De Felici, M., Camaioni, A., Russo, A. M., and Siracusa, G. (1990). Selective binding of mouse and human spermatozoa to beads coated with extracellular matrix components. Molec. Repr. Dev. 27, 337-343.
 
28) Dolci, S., Bertolani, M.V., Canipari, R. and De Felici, M. (1991). Involvement of carbohydrates in the hardening of the zona pellucida of mouse oocytes. Cell. Biol. Inter. Rep. 15, 571-579.
 
29) De Felici, M., Dolci, S., and Siracusa, G. (1991). An increase of intracellular free calcium is essential for spontaneous meiotic resumption by mouse oocytes. J. Exp. Zool. 260, 401-405.
 
30) De Felici, M., and Dolci, S. (1991). Leukemia inhibitory factor sustains the survival of mouse primordial germ cells cultured on TM4 feeder layers. Dev. Biol. 147, 281-284.
 
31) De Felici, M., Dolci, S., and Pesce, M. (1992).  Cellular and molecular aspects of mouse primordial germ cells migration and proliferation. Int. J. Dev. Biol. 36, 205-213.
 
32) De Felici, M., Dolci, S., and Pesce, M. (1993). Proliferation of mouse primordial germ cells in vitro: a key role for cAMP. Dev. Biol. 157, 227-280.
 
33) Dolci, S., Pesce, M., and De Felici, M. (1993). Combined action of stem cell factor, leukemia inhibitory factor, and cAMP on in vitro proliferation of mouse primordial germ cells. Mol. Repr. Dev. 35, 134-139.
 
34) Pesce, M., Farace, M.G., Piacentini, M., Dolci, S., and De Felici, M. (1993). Stem cell factor and leukemia inhibitory factor promote primordial germ cell survival by suppressing programmed cell death (apoptosis). Development 118, 1089-1094.
 
35) Russo, M.A., Odorisio T., Fradeani, A., Laura Rienzi, De Felici, M., Cattaneo, A., and Siracusa, G. (1994). Low affinity nerve growth factor receptor is expressed during testicular morphogenesis and in germ cells at specific stages of spermatogenesis. Mol. Reprod. Dev. 37, 157-166.
 
36) De Felici, M., and Pesce, M. (1994). Growth factors in mouse germ cell migration and proliferation. Progress in Growth Factor Res. 5, 135-143.
 
37) Pesce, M., Siracusa, G., Giustiniani Q., and De Felici, M. (1994). Histotypic in vitro reorganization of dissociated cells from mouse fetal gonads. Differentiation 56, 137-142.
 
38) Pesce, M., and De Felici, M. (1994). Apoptosis in mouse primordial germ cells: a study by transmission and scanning electron microscope. Anat. Embryol. 189, 435-440.
 
39) De Felici, M., and Pesce, M. (1994). Interactions between migratory primordial germ cells and cellular substrates. In: Germline Development. Ciba Foundation Symposium No. 182. (Goodie J. ed.), pp- 140-153. 
 
40) De Felici, M., and Pesce. M. (1995). Immunoaffinity purification of migratory mouse primordial germ cells. Exp. Cell. Res. 216, 277-279.
 
41) Pesce, M., and De Felici, M. (1995). Purification of mouse primordial germ cells by MiniMACS magnetic separation system. Dev. Biol. 170, 722-725.
 
42) Pesce, M., Canipari, R., Ferri, G.L., Siracusa, G., and De Felici, M. (1996). Pituitary adenylate cyclase activating-polypeptide (PACAP) stimulates adenylate cyclase and promotes proliferation of mouse primordial germ cells. Development 122, 215-221.
 
43) Cecconi S., Rossi G., De Felici M., and Colonna R. (1996). Mammalian oocyte growth in vitro is stimulated by soluble factor(s) produced by prenatal granulosa cells and by Sertoli cells. Mol. Repr. Dev. 44, 540-546.
 
44) De Felici, M. (1996). How life may come from death: lessons from reproductive biology. Cell Death and Differ. 3, 439-441.
 
45) Morena, A.R., Boitani, C., Pesce, M., De Felici, M., Stefanini, M.. (1996). Isolation of highly purified type A spermatogonia from prupubertal testis. J. Andr. 17, 708-717.
 
46) De Felici, M., Di Carlo, A., Pesce, M. (1996). Role of Stem Cell Factor in somatic-germ cell interactions during prenatal oogenesis. Zygote 4, 349-351.
 
47) Russo. M., Giustizieri M.L., Farini, D., Campagnolo L., De Felici, M., Siracusa, G. (1996). Expression of the p75 neurotrophin receptor in the developing and adult testis of the rat. Int. Dev. Biol. Suppl. 1, 227-228.
 
48) Pesce, M., Cerrito, M.G., Travia, G., Russo M.A., De Felici, M. (1996). In vitro development of growing oocytes from fetal and early postnatal mouse ovaries. Int. Dev. Biol. Suppl. 1, 229-230.
 
49) De Felici, M. (1997). Ovarian follicular atresia: a model for apoptosis. Cell Death Diff. 4, 260-261.
 
50) De Felici, M. (1997). Apoptosis in reproduction biology. Cell Death Diff. 4, 169-170. 
           
51) Pesce, M., Di Carlo, A. and De Felici, M. (1997). The c-kit receptor is involved in the adhesion of mouse primordial germ cells to somatic cells in culture. Mech. Dev. 69, 37-47.
 
52) De Felici, M., Pesce M., Giustiniani Q., and Di Carlo, A. (1998). In vitro adhesiveness of mouse primordial germ cells to cellular and extracellular matrix component substrata. Micr. Res. Techn. 43, 258-264.
 
53)  De Felici, M. (1998). In vitro culture systems for germ cells from mouse embryo: primordial germ cells and oocytes.  In vitro germ cell develomental toxicology: from science to social and industrial demand. Adv. Exp. Med. Biol. 444, 41-49.
 
54) Faussone-Pellegrini, MS, Matini P. and De Felici, M. (1999). The cytoskeleton of the mesenteric neurons during murine embryonic life. Anat. Embryol. 199, 459-469.
 
55) Dell’Aquila, M.E., De Felici, M., Massari, S., Maritano, F., and Minnoia, M. (1999).  Effects of fetuin on the zona pellucida hardening and fertilizability of in vitro matured equine oocytes. Biol. Repr. 61, 533-540.
 
56) De Felici, M., Di Carlo A., Pesce, M., Iona S., Farrace, MG, Piacentini, M. (1999). Bcl-2 and Bax regulation of apoptosis in germ cells during prenatal oogenesis in the mouse embryo. Cell Death Diff. 6, 908-915.
 
57) Di Carlo, A., Travia, G., De Felici, M. (2000).  The meiotic specific synaptonemal complex protein SCP3 is expressed by female and male primordial germ cells of the mouse embryo. Int. J. Dev. Biol. 44, 241-244.
 
58) Maccarrone, M., De Felici, M., Bari, M., Klinger, F., Siracusa , G., Finazzi-Agrò , A. (2000). Down-regulation of anandamide hydrolase in mouse uterus by sex hormones. Eur. J. Biochem. 267, 1-8.
 
59) De Felici, M. Regulation of primordial germ cell development in the mouse (2000). Int. J. Dev. Biol. 44, 575-580.
 
60) De Felici, M. and Siracusa, G. The rise of embryology in Italy from the Reinassance to early 1900 (2000). Int. J. Dev. Biol. 44, 515-521.
 
61) Di Carlo, A. and De Felici, M. A role for E-Cadherin in mouse primordial germ cell development (2000). Dev. Biol. 226, 209-219.
 
62) Butteroni, C., De Felici, M., Scholer, H.R., and Pesce, M. (2000). Phage display screening reveals an association between germline-specifc trancription factor Oct-4 and multiple cellular proteins. J. Mol. Biol. 304: 529-540.
 
63) De Felici, M. Twenty years of researches on primordial germ cells. (2001). Int. J. Dev. Biol. 45: 519-522.
 
64) Manna C., Rienzi, L., Greco, E., Sbracia, A., Rahman, A., Poverini, R., Siracusa, G., and De Felici, M. (2001). Zona pellucida solubility and cortical granule complements in human oocytes following assisted reproductive techniques. Zygote 9: 201-210.
 
65) Pesce, M., Klinger, F., and De Felici, M. (2002). Derivation in culture of primordial germ cells from the mouse epiblast: phenotipic induction and growth control by Bmp4 signalling. Mech. Dev. 112, 15-24.
 
66) S. Iona., F. G. Klinger, R, Sisti, R. Ciccalese, A. Nunziata and De Felici, M. (2002). A comparative study of cytotoxicity effects by N-ethyl-N-nitrosourea, adriamycin and mono- (2-ethylhexyL)-phthalate on mouse primordial germ cells. Cell Biol.Toxicol 18, 131-145. 
67) Klinger, F. and De Felici M. (2002). In vitro development of growing oocytes from fetal mouse oocytes: stage-specific regulation by stem cell factor and granulosa cells. Dev. Biol. 244, 85-95.
 
68) Doneda, L., Klinger, F. G., Larizza , L. and De Felici, M.(2002). KL/KIT co-expression in mouse fetal oocytes. Int. J. Dev. Biol. 461015-1021 
69) Klinger F.G., Scaldaferri M. L., Di Carlo A., Baiocco, M., Coletta, M., Cossu, G. and De Felici M. (2003)  Myogenic potential of mouse primordial germ cells.  Int. J. Dev. Biol. 47, 303-305, 2003. 
70) Lees-Murdock, D, J., De Felici M., and Walsh, C. P .(2003).  Methylation dynamics of repetitive DNA elements in the mouse germ lineage. Genomics 82: 230-237.
 
71) Cairns  LA, Moroni E, Levantin E., Giorgetti A., Klinger FG, Ronzoni S, Tatangelo L, Tiveron C.  De Felici M, Dolci S, Magli MC, Giglioni B. and Ottolenghi S (2003). c-Kit regulatory elements required to recapitulate correct developmental expression in hematopoietic and germ cell lineages. Blood 102, 3954-3962.
 
72) Moe-Behrens G, Klinger FG, Eskild W, Grotmol T, Haugen TB and De Felici  M (2003). Akt/PTEN signaling mediates estrogen-dependent proliferation of primordial germ cells in vitro. Mol. Endocrinol. 17, 2630-2638.
 
73) Maccarrone M., De Felici, M. , Klinger F.G., Battista N., Siracusa, G and Finazzi-Agrò A. (2004). Mouse blastocysts release a lipid which activates anandamide hydrolase in intact uterus. Mol. Human Repr. 10, 215-221.
 
74) De Felici M, Scaldaferri ML, Lobascio M, Iona S, Klinger FG and Farini D (2004). In vitro approaches to the study of primordial germ cell lineage and proliferation. Human Repr. Update 10, 197-206, 2004
 
75) Lees-Murdock, DJL, Shovlin TC, Gardiner T, De Felici M, Walsh CP (2005). DNA methyltransferase expression in the mouse germ line during periods of de novo methylation. Dev. Dynamics 232, 992-1092. 
76) De Felici, M., Klinger F., Farini, D., Scaldaferri, M.L., Iona S., and Lobascio, M. (2005). Establishment of the oocyte population in the fetal ovary: primordial germ cell proliferation and oocyte programmed cell death. RBD 10, 182-191.
 
77) De Felici, M., Scaldaferri ML and Farini D. (2005). Adhesion molecules for mouse primordial germ cells. FBS 10, 542-551. 
78) Farini , D., M. L. Scaldaferri, S. Iona, La Sala G., and De Felici, M. (2005) Growth factors sustain primordial germ cell survival, proliferation and entering into meiosis in the absence of somatic cells. Dev. Biol. 285, 49-56.
 
79) Sangiuolo, F., Filareto A., Spitaleri, P., Scaldaferri ML., Mango R., Bruscia E., Citro, G., Bruneltti E., De Felici M., and Novelli G. (2005). In vitro restoration of functional SMN protein in human trophoblast cells affected by spinal muscular atrophy by small fragment homologous replacement. Human Gene Ther. 16, 869-880.
 
80) Claudia Giampietri, Simonetta Petrungaro, Francesca G. Klinger, Pierpaolo Coluccia, Alessio Paone, Elisabetta Vivarelli, Antonio Filippini, Paola De Cesaris, Massimo De Felici, Elio Ziparo. (2006) c-FLIP expression and function in fetal mouse gonocytes. Faseb J  20, 124-6.
 
81) Klinger F.G, Battista N, De Felici M, Maccarrone M (2006). Stage-variations of anandamide hydrolase activity in mouse uterus during the natural oestrus cycle. JECAR 3, 1-4.
 
82) Galan J.J., De Felici M, Buch B, Rivero M.C., Segura A., Royo J.L., Cruz N., Real L.M., Ruiz A. (2006) Genetic association study of KIT/KITLG system in human male infertility. Human Repr 21, 3185-3195.
 
83) Lobascio, A. M., Klinger F. G. and DE FELICI, M. (2007) Isolation of apoptotic mouse fetal oocytes by AnnexinV assay. Int J Dev Biol 51, 157-160.
 
84) Sorrentino E., Nazzicone V., Farini D., Campagnolo L., and De Felici, M. (2007)
Comparative transcript profiles of cell cycle-related genes in mouse primordial germ cells, embryonic stem cells and embryonic germ cells. Gene Expression Patterns 7, 714-721
 
85)  Donatella Farini, Gina La Sala, Marianna Tedesco and Massimo De Felici (2007)
Chemoattractant action and molecular signaling pathways of Kit Ligand on mouse primordial germ cells.  Dev. Biol 306, 572-583.
 
86) LOBASCIO, A. M., KLINGER F.G., SCALDAFERRI, M.L., FARINI, D., and DE FELICI, M. (2007)
Analysis of programmed cell death in mouse fetal oocytes. Reproduction 134, 241-252
 
87) Maranghi F, Rescia M, Macrì C, Di Consiglio E, De Angelis G, Testai E, Farini D, De Felici M, Lorenzetti S, Mantovani A  (2007) Lindane may modulate the female reproductive development through the interaction with ER-beta: an in vivo-in vitro approach.  Chem Biol Interact. 169, 1-14.
 
88) Cristina Eguizabal, María D. Boyano, Alejandro Díez-Torre, Unai Silván, Noelia Andollo, Ricardo Andrade, Jon Arlucea , Massimo De Felici and Juan Aréchaga. (2007) Interleukin-2 induces the proliferation of mouse primordial germ cell I J Dev Biol 51:731-738.
 
89) Sangiuolo F., Scaldaferri ML., Filareto A., Spitalieri P., Mango R., Bruscia E., Gruenert DC., De Felici M., Novelli G. (2008)  CFTR gene trageting in mouse embryonic stem cells mediated by Small Fragment Homologous Replacement (SFHR). Front. in Biosc. 13, 2989-2999.
 
90) Massimo De Felici, Anna Maria Lobascio and Francesca Gioia Klinger. Cell death in fetal oocytes: many players for multiple pathways. (2008). Autophagya 4, 240-243.
 
91) Claudia Montani, Marialetizia Penza, Marija Jeremic, Giorgio Biasotto, Gina La Sala, Massimo De Felici, Paolo Ciana, Adriana Maggi and Diego Di Lorenzo (2008). Genistein is an Efficient Estrogen in the Whole-Body throughout Mouse Development. Toxicological Sciences 103:57-67. 
92) Lees-Murdock DJ., Lan HT., Gardiner TA., Castrillon DH., De Felici M., Walsh CP. (2008).  DNA methyltransferase loading, but not de novo methylation, is an oocyte-autonomous process stimulated by SCF signalling. Dev Biol 321:238-235.
 
93) C. Montani, M. Penza, M. Jeremic, G. Rando, P. Ciana, A. Maggi, G. La Sala, M. De Felici, and Di Lorenzo D. (2009). Estrogen receptor-mediated transcriptional activity of genistein in the mouse testis. Ann. N.Y. Acad. Sci.1163: 475-477.
 
94) Gina La Sala, Donatella Farini, Massimo De Felici (2009). Pro-apoptotic effects of lindane on mouse primordial germ cells. Toxicological Science 108 :445-451.
 
95) Massimo De Felici, Donatella Farini and Susanna Dolci (2009). In or Out Stemness: Comparing Growth Factor Signalling in Mouse Embryonic Stem Cells and Primordial Germ Cells. Current Stem Cell Research & Therapy 4: 87-97.
96) Massimo De Felici (2009). Primordial germ cells at the beginning of the XXI century. IJDB 53: 891-894.
97) Massimo De Felici and Rita Canipari (2009). XIV Workshop on the Development and Function of the Reproductive Organs. IJDB 53: 883-889.
 
 
98) Stefania Gonfloni, Lucia Di Tella, Sara Caldarola, Stefano Cannata, Francesca G. Klinger Claudia Di Bartolomeo, Maurizio Mattei, Eleonora Candi, Massimo De Felici, Gerry Melino and Gianni Cesareni (2009). Inhibition of the c-Abl/TAp63 pathway protects mouse oocytes from chemotherapy-induced death. Nature Medicine 15: 1179-1185.
 
99) Paola Spitalieri, Giancarlo Cortese, Adalgisa Pietropolli, Antonio Filareto, Susanna Dolci, Francesca Gioia Klinger, Emiliano Giardina, Silvia Di Cesare, Laura Bernardini, Davide Lauro, Lucia Scaldaferri, Gennaro Citro, Giuseppe Novelli, Massimo De Felici and Federica Sangiuolo (2009). Identification of Multipotent Cytotrophoblast Cells from Human First Trimester Chorionic Villi. Cloning and Stem Cells 11(4):535-56.
 
100) Marianna Tedesco, Gina La Sala, Massimo De Felici, and Donatella Farini (2009). Nuclear-cytoplasm shuttling and DNA transactivation activity of Stimulated by Retinoic Acid gene 8 (Stra8). J Biol Chem 284(51): 35781 - 35793.
 
101) Florencia Barrios, Doria Filipponi, Manuela Pellegrini,  Maria Paola Paronetto, Raffaele Geremia, Massimo De Felici,  Emmanuele A. Jannini, Pellegrino Rossi and Susanna Dolci (2010). FGF9 and RA modulate Nanos2 expression in premeiotic germ cells. J. Cell Science 123: 871-880.
 
102) La Sala Gina, Farini Donatella and De Felici Massimo (2010). Estrogenic in vitro assay on mouse embryonic Leydig cells. Int. J. Dev. Biol. 54: 717-722. 
103) De Felici M. (2010) Germ stem cells in the mammalian adult ovary: considerations by a fan of the primordial germ cells. Mol. Hum. Reprod. 16: 632-636.
104) Gina La Sala, Donatella Farini and Massimo De Felici (2010) Rapid estrogen signalling in mouse primordial germ cells. Exp. Cell Res. 316:1716-1727.
 
105) Enrica Bianchi, Federica Barbagallo, Claudia Valeri1, Raffaele Geremia, Antonietta Salustri,
Massimo De Felici and Claudio Sette  (2010) Ablation of the Sam68 gene impairs female fertility and gonadotropin-dependent follicle development . Human Mol Genetics doi: 0.1093/hmg/ddq422
 
106) Monica Bari, Marianna Tedesco, Natalia Battista,  Nicoletta Pasquariello, Mariangela Pucci, Valeria Gasperi, Maria Lucia Scaldaferri, Donatella Farini, Massimo De Felici and Mauro Maccarrone  (2011). Characterization of the endocannabinoid system in mouse embryonic stem cells. Stem Cells and Development  20: 139-147.
 
107) Maria Lucia Scaldaferri, Stefania Fera, Ilaria Falciatori , Laura Grisanti, Mario Stefanini, Massimo De Felici and Elena Vicini (2011). Identification of side population cells in mouse primordial germ cells and prenatal testis. Int J Dev Biol 55: 209-214.
 
108) Marianna Tedesco, Donatella Farini and Massimo De Felici  (2011) Impaired meiotic competence in putative germ cells produced from mouse embryonic stem cells. Int J Dev Biol
 55: 215 – 222.
 
109) Valeri Claudia Valeri, Sebastiana Pappalardo, Massimo De Felici and Claudio Manna
CORRELATION OF OOCYTE MORPHOMETRY PARAMETERS WITH WOMAN'S AGE (2011).  Journal of Assisted Reproduction and Genetics 28, 545-552, DOI: 10.1007/s10815-011-9555-3.
 
110) De Felici, M. (2011) Nuclear reprogramming in mouse primordial germ cells: epigenetic
contribution. Stem Cell International. Article ID 425863, doi:10.4061/2011/425863
 
111) Antonio Libonati, Giuseppe Marzo, Francesca G Klinger, Donatella Farini, Gianni Gallusi, Simona Tecco, Stefano Mummolo, Massimo De Felici and Vincenzo Campanella (2011). Embryotoxicity assays for leached components from dental restorative materials. Reproductive Biology and Endocrinology 9:136 doi:10.1186/1477-7827-9-136. 
 
112) De Felici M. and Farini D (2012). The control of mouse primordial germ cell cycle: old and new players. In: New Frontiers in Fertility and Reproduction. Current Pharmaceutical Design 18:233-44.
 
113) Emiliano Maiani,Claudia Di Bartolomeo,Francesca G Klinger,Stefano M Cannata,Sergio Bernardini,Sebastien Chateauvieux, Fabienne Mack,Maurizio Mattei, Massimo De Felici,Marc Diederich,Gianni Cesareni & Stefania Gonfloni (2012) Reply to: Cisplatin-induced primordial follicle oocyte killing and loss of fertility are not prevented by imatinib. Nature Medicine Volume:
18, Pages:
1172–1174 Year published:
(2012) DOI:
doi:10.1038/nm.2852
 
114) Daniel J. Klionsky et al., Guidelines for the use and interpretation of assays for monitoring autophagy (2012).  Autophagy 8  (4) Volume 8, Issue 4 April 2012 Pages 445 – 544 http://dx.doi.org/10.4161/auto.19496
 
115) Zhi-Peng Zhan, Gui-Jin Liang, Xi-Feng Zhang, Guo-Liang Zhang, Hu-He Chao, Lan Li, Xiao-Feng Sun, Ling-Jiang Min, Qing-Jie Pan, Qing-Hua Shi, Qing-Yuan Sun, Massimo De Felici, Wei Shen (2012). Growth of mouse oocytes to maturity from premeiotic germ cells in vitro. PLoS One. 2012;7(7):e41771. doi: 10.1371/journal.pone.0041771. Epub 2012 Jul 24.
 
116) Fabio Ciccarone, Francesca Gioia Klinger, Angela Catizone, Roberta Calabrese, Michele
Zampieri, Maria Giulia Bacalini, Massimo De Felici and Paola Caiafa (2012). Poly(ADP-ribosyl)ation Acts in the DNA Demethylation of Mouse Primordial Germ Cells Also with DNA Damage-Independent Roles. PLoS One. 2012;7(10):e46927. doi: 10.1371.
 
117) Bo Chen, Lian-Jun Zhang, Jie Tang, Xin-Lei Feng, Yan-Min Feng, Gui-Jin Liang, Lin-Qing Wang1, Yan-Ni Feng, Lan Li, Massimo De Felici, Qing-Hua Shi, Wei Shen (2013) Recovery of Functional Oocytes from Cultured Premeiotic Germ Cells after Kidney Capsule Transplantation. Stem Cells and Development. February 2013, Vol. 22, No. 4: 567-580 PMID: 22978409
 
118) Massimo De Felici and Susanna Dolci (2013) Male germ cells and cancer:  a connection among pluripotency, differentiation  and stem cell biology. IJDB 57, 101, 2013.
 
119) Massimo De Felici and Susanna Dolci (2013) From testis to teratomas: a brief history of male germ cells in mammals. IJDB 57, 115-121.
 
120) Jesús del Mazo, MIGUEL A. BRIEÑO-ENRÍQUEZ, JESÚS GARCÍA-LÓPEZ, LUIS A. LÓPEZ-FERNÁNDEZ and Massimo De Felici (2013). Endocrine disruptors, gene deregulation and male germ cell tumors. IJDB 57, 225-239.
 
121) De Felici M., F. Barrios  (2013). Seeking the origin of female germline stem cells in the mammalian ovary. Reproduction 146, 125–130.
 
122) Marianna Tedesco, Maria Giovanna Desimio, Francesca Gioia Klinger, Massimo De Felici, Donatella Farini (2013). Minimal concentrations of retinoic acid induces Stra8-dependent meiosis directly in mouse primordial germ cells. Biol Repr 88, 145, 1-11.
 
123) Zhang XF, Zhang LJ, Li L, Feng YN, Chen B, Ma JM, Huynh E, Shi QH, De Felici M, Shen W. (2013). Diethylhexyl phthalate exposure impairs follicular development and affects oocyte maturation in the mouse. Environ Mol Mutagen.  54:354-361. doi: 10.1002/em.21776. 
124) Yan-Min Feng, Bo Pan, Gui-Jin Liang, Xun-Si Qin, Xi-Feng Zhang, Chun-Lei Chen, Lan Li, Shun-Feng Cheng, Massimo De Felici, Wei Shen. (2014). Notch pathway regulates female germ cell meiosis progression and early oogenesis events in fetal mouse. Cell Cycle 13(5), 782-91. doi: 10.4161/cc.27708
 
125) Teng Zhang, Lan Li, Xi-Feng Zhang, Yang Zhou, Jing-Cai Liu, Lin-Qing Wang, Massimo De Felici, Hong Chen, Guo-Qing Qin, Wei Shen. Di-(2-ethylhexyl) Phthalate and Bisphenol A Exposure Impairs Mouse Primordial Follicle Assembly. (2014).  Environ Mol Mutagen. doi: 10.1002/em.21847.
 
 126) Massimo De Felici (2014). One hundred years but they do not show them. Austin J In Vitro Fertilization 1 (2 ), 1.
 
127) Lobascio AM, De Felici M, Anibaldi M, Greco P, Minasi MG, Greco E.(2015). Lobascio AM, De Felici M, Anibaldi M, Greco P, Minasi MG, Greco E.(2015).  Andrology. 2015 Mar;3(2):265-70. doi:10.1111/andr.302.
 
128) Desimio MG, Campolo F, Dolci S, De Felici M, Farini D. (2015). SOHLH1 and SOHLH2 directly down-regulate STIMULATED BY RETINOIC ACID 8 (STRA8) expression. Cell Cycle. 2015;14(7):1036-45. doi: 10.1080/15384101.2015.1007721
 
129) Scaldaferri ML, Klinger FG, Farini D, Di Carlo A, Carsetti R, Giorda E, De Felici M. (2015). Hematopoietic activity in putative mouse primordial germ cell populations. Mech Dev 136:53-63. doi: 10.1016/j.mod.2015.02.002.
 
130) Fu XF, Cheng SF, Wang LQ, Yin S, De Felici M, Shen W (2015). DAZ Family Proteins, Key Players for Germ Cell Development.  DAZ Family Proteins, Key Players for Germ Cell Development.  Int J Biol Sci. 2015 Aug 15;11(10):1226-35. doi: 10.7150/ijbs.11536.
 
131) Liang GJ, Zhang XF, Wang JJ, Sun YC, Sun XF, Cheng SF, Li L, De Felici M, Shen W. (2015). Activin A Accelerates the Progression of Fetal Oocytes Throughout Meiosis and Early Oogenesis in the Mouse. Stem Cell Dev. Oct 15;24(20):2455-65. doi: 10.1089/scd.2015.0068. Epub 2015 Jul 30.PMID:26083127.
 
132) Klinger FG, Rossi V, De Felici M (2015). Multifaceted programmed cell death in the mammalian fetal ovary. Int J Dev Biol. 2015;59(1-3):51-4. doi: 10.1387/ijdb.150063fk.
 
133) De Felici M, Klinger FG. (2015). Programmed cell death in mouse primordial germ cells. Int J Dev Biol. 2015;59(1-3):41-9. doi: 10.1387/ijdb.150064md.
134) De Felici M, Piacentini M. (2015). Programmed Cell death in Development and Tumors. Int J Dev Biol. 2015;59 (1-3):1-3. doi: 10.1387/ijdb.150168md.
 
135) Wei Ge, Chunlei Chen, Massimo De Felici, Wei Shen  (2015). In vitro differentiation of germ cells from stem cells: a comparison between primordial germ cells and in vitro derived primordial germ cell-like cells. Cell Death Disease. 15;6:e1906. doi: 10.1038/cddis.2015.265.
 
136) Susanna Dolci, Federica Campolo and Massimo De Felici (2015). Gonad development and germ cell tumors in mouse and human. Development and pathology of the gonad. Semin Cell Dev Biol. 2015 Sep;45:114-23. doi: 10.1016/j.semcdb.2015.10.002. Epub 2015 Oct 9.
 
137) Dorian Nomacki,  et al. (2015). Effect of culture in simulated microgravity on the development  of mouse embryonic testes.  Adv Clin Exp Med 2015, 24, 5, 769–774 DOI: 10.17219/acem/27920.
 
138) Massimo De Felici and Gina La Sala (2015). Epigenetic reprogramming in the mammalian germ line: possible effects by endocrine disruptors on primordial germ cells. Open Biotechnology Journal Volume 10, Issue Suppl-1, M4, 1 March 2016, Pages 36-41.
 
139) Han Z, Yan Q, Ge W, Liu ZG, Gurunathan S, De Felici M, Shen W, Zhang XF (2016). Cytotoxic effects of ZnO nanoparticles on mouse testicular cells. International Journal of Nanomedicine 11:5187-5203.
 
140) Zhang Teng, Shen Wei, Massimo De Felici, Zhang Xi-Feng (2016) Di(2-ethylhexyl)phthalate: adverse effects on folliculogenesis that cannot be neglected. Environ Mol Mutagen. 2016 Aug 17. doi: 10.1002/em.22037. [Epub ahead of print] Review. PMID:27530864..
 
141) Wei Ge, Shun-Feng Cheng , Paul W. Dyce, Massimo De Felici, Wei Shen (2016). Skin-derived stem cells as potential candidate for the cell therapy of infertility. Cell Death and Disease 7, e2471.
 
142) De Felici M. (2016) The Formation and Migration of Primordial Germ Cells in Mouse and Man. Results Probl Cell Differ. 2016;58:23-46. doi: 10.1007/978-3-319-31973-5_2.
 
143) Lai FN, Liu JC, Li L, Ma JY, Liu XL, Liu YP, Zhang XF, Chen H, De Felici M, Dyce PW, Shen W. (2017). Di (2-ethylhexyl) phthalate impairs steroidogenesis in ovarian follicular cells of prepuberal mice. Arch Toxicol. 2017 Jan;24(1):72-82. doi: 10.1038/cdd.2016.97
 
144) V. Rossi, M. Lispi, S. Longobardi, M. Mattei, F. Di Rella, A. Salustri, M. De Felici, F. G. Klinger (2017). LH prevents cisplatin induced cell death of ovarian reserve oocytes and preserves female fertility in the mouse Cell Death and Differentiation. Cell Death Differ. 2017 Jan;24(1):72-82. doi: 10.1038/cdd.2016.97.
 
145) Wei Shen, Yong-Yong Wang, Yuanchao Sun, Xiaofeng Sun, Shunfeng Cheng, Bo Li, Xifeng Zhang, and Massimo De Felici. (2017). Starvation at birth impairs germ cell cyst breakdown and increases autophagy and apoptosis in mouse oocytes. Cell Death Dis. 2017 Feb 9;8(2):e2613. doi: 10.1038/cddis.2017.3.
 
146) Jing-Cai Liu, Fang-Nong Lai, Xiao-Feng Sun, Shun-Feng Cheng, Wei Ge, Yu-Feng Wang, Lan Li , Massimo De Felici, Paul W. Dyce, Wei Shen.  (2017). Di (2-ethylhexyl) phthalate exposure impairs meiotic progression and DNA damage repair in fetal oocytes in vitro. Cell Death Dis. 2017 Aug 3;8(8):e2966. doi: 10.1038/cddis.2017.350.
 
147) Jun-Jie Wang, Xiao-Feng Sun, Sheng-Feng Cheng , Wei Ge , Jing-Cai Liu , Francesca Gioia Klinger, Massimo De Felici, Wei Shen  (2017). Complete in vitro oogenesis: retrospects and prospects. Cell Death Differ. 2017 Aug 25. doi: 10.1038/cdd.2017.134. [Epub ahead of print] Review.
 
148) Xi-Feng Zhang, Feng-Hua Huang, Guo-Liang Zhang, Ding-Ping Bai, De Felici Massimo, Yi-Fan Huang, Sangiliyandi Gurunathan (2017). Novel biomolecule lycopene-reduced graphene oxide-silver nanoparticle enhances apoptotic potential of trichostatin A in human ovarian cancer cells (SKOV3). International Journal of Nanomedicine 2017:12 7551–7575.

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