ASSOCIATE

e-mail: p.grimaldi@med.uniroma2.it
Telefono: +39 06 7259 6254
SSD: BIO/16
SC: 05/H1
Macro-area:
Anatomia Umana
Campi di interesse: 
- Spermatogenesi
- Sistema endocannabinoide


 

 Prof. Paola Grimaldi

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​CURRICULUM VITAE

Education:
1985:                   Doctor cum Laude in Biological Sciences, University of Rome La Sapienza (Rome, Italy)
1992:                   PhD in Morphogenetic and Cytological Science, University of Rome La Sapienza, (Rome)
1994-2014:        Assistant Professor of Human Anatomy at the Department of Biomedicine and Prevention, University of Rome Tor Vergata, (Italy).
2014 to date:    Associate Professor of Human Anatomy at the Department of Biomedicine and Prevention, University of Rome Tor Vergata, (Italy)

Scientific Interests
The main interests are centered around the spermatogenesis, focusing on:

1. Hormonal dependent gene expression in mouse Sertoli cells
2. Intrinsic and extrinsic factors that regulate proliferation, differentiation  and meiotic entry of mouse male mitotic germ cells.
3. Molecular analysis of genetic causes in patients affected by sex-reversal, pseudoermaphroditism, infertility and altered sex development
4. Study of the endocannabinoid system and its role in male and female reproduction
5. Study of the endocannabinoid system and its role in neural stem cells

News 

- Medical research. Com
​- Science daily
- Eureka alert

SELECTED PAPERS

• Grimaldi P, Rossi G, Catanzaro G and Maccarrone M. Modulation of the endocannabinoid-degrading enzyme fatty acid amine hydrolase by follicle- stimulating hormone. Vitamins&Horm. 2009;81
• Grimaldi P, Orlando P, Di Siena S, Lolicato F, Petrosino S, Bisogno T, Geremia R, De Petrocellis L and Di Marzo V. The endocannabinoid system and pivotal role of CB2 receptor in mouse spermatogenesis. PNAS 2009; 106(27):11131-6
• Pellegrini M, Di Siena S, Claps G, Di Cesare S, Dolci S, Rossi P, Geremia R, Grimaldi P. Microgravity Promotes Differentiation and Meiotic Entry of Postnatal Mouse Male Germ Cells. PLoS One. 2010,5(2):e9064.
• Grimaldi P, Pucci M, Di Siena S, Di Giacomo D, Pirazzi V, Geremia R, Maccarrone M. The faah gene is the first direct target of estrogen in the testis: role of histone demethylase LSD1. Cell Mol Life Sci 2012 ;69(24):4177-90
• Compagnucci C, Di Siena S, Bustamante MB, Di Giacomo D, Di Tommaso M, Maccarrone M, Grimaldi P and Sette C. Type-1 (CB1) cannabinoid receptor promotes neuronal differentiation and maturation of neural stem cells . PLoS ONE 2013 8(1): e54271.