Department of Biomedicine and Prevention
  • Homepage
  • Department
    • Organization and Governance
    • Staff
  • Research
  • Didactic
    • Specialization School in Nutrition Science Università Cattolica Nostra Signora del Buon Consiglio
    • Scuola di Specializzazione in Scienza dell' Alimentazione
    • Scuola di Specializzazione di Igiene e Medicina Preventiva
    • Scuola di Specializzazione in Radioterapia
    • Scuola di Specializzazione di Radiodiagnostica
    • Scuola di Specializzazione in Ematologia
    • Medical genetics Graduated School
    • master_II_Level_Cytogenetics
    • master_II_Level_CBRNE
    • master_I_Level_PH. E. SOUCHARD
    • master_I_Level_CBRNE
    • master_I_Level_Nursing_Managment
    • master_I_Level_Critical_Nursing
    • master_I_Level_Stomaterapia
    • Corso_professionale_Nursery_midwifery_operating_room
  • Third Mission
    • Conventions
    • Laboratory of Environmental Microbiology
    • Environmental Chemistry Laboratory
    • ICP-Massa Laboratory
    • Laboratory of Forensic Genetics
    • Laboratory of Industrial Hygiene
    • Laboratory of Medical Genetics
    • Laboratory of Oncohematology
    • Section of Histology and Embryology-Laboratories of Reproductive and Developmental Biology
    • Section of Legal Medicine
    • Section of of Clinical Nutrition and Nutrigenomics
    • Simulation and Optimization Laboratory of National Health Service (SSN) Services
    • Laboratory for Primordial Cell Germ Study en
    • Laboratory for the Prevention and Management of Psychosocial Risks (stress, mobbing and burn out)
    • Laboratory of Environmental and Occupational Toxicology
    • Laboratorio of Human Anatomy
  • SUA-RD_en
    • Report on Research Planning 2014-2015
    • Research Report
    • Papers on SCOPUS
    • Statistics and Metrics
    • Research lines
  • Positions and Announcements
    • Positions
    • Commitments to third parties
  • In Evidence
  • News_en
  • Home
  • Dipartimento
    • Organizzazione e Governance
    • Personale
  • Ricerca
    • Dottorati di ricerca
  • Didattica
    • Scuola di Specializzazione in Scienze dell'Alimentazione (Università Cattolica Nostra Signora del Buon Consiglio)
    • Scuola di Specializzazione in Scienza dell' Alimentazione
    • Scuola di Specializzazione di Igiene e Medicina Preventiva >
      • LIBRETTO SCUOLA SPECIALIZZAZIONE
    • Scuola di Specializzazione in Radioterapia
    • Scuola di Specializzazione di Radiodiagnostica
    • Scuola di Specializzazione in Ematologia
    • Scuola di Specializzazione in Genetica Medica
    • master_II_Livello_Citogenetica
    • master_II_Livello_CBRNE
    • master_I_Livello_PH. E. SOUCHARD
    • master_I_Livello_CBRNE
    • master_I_Livello_Nursing_Managment
    • master_I_Livello_Critical_Nursing
    • master_I_Livello_Stomaterapia
    • Corso_professionale_Infermiere_Ostetrica_sala_operatoria
  • Terza Missione
    • Convenzioni
    • Laboratorio di Microbiologia Ambientale
    • Laboratorio di Chimica Ambientale
    • Laboratorio ICP-Massa
    • Laboratorio di Genetica Forense
    • Laboratorio di Genetica Medica
    • Sezione di Medicina Legale
    • Laboratorio di Oncoematologia
    • Laboratorio di Igiene Industriale
    • Laboratory for Primordial Cell Germ Study
    • Laboratorio dei Rischi Psicosociali
    • Sezione di Istologia ed Embriologia - Laboratorio di Biologia della Riproduzione e dello Sviluppo
    • Laboratorio di Simulazione - SSN
    • Laboratorio di Tossicologia Ambientale ed Occupazionale
    • Laboratori Sezione di Biologia
    • Laboratory of Human Anatomy
    • Sezione di Nutrizione clinica e Nutrigenomica
  • SUA-RD
    • Relazione Ricerca
    • Relazione Programmazione Ricerca
    • Elenco Pubblicazioni Scopus
    • Statistiche e Metriche
    • Linee di Ricerca
  • News
  • Bandi e Concorsi
    • Concorsi
    • Affidamento incarichi c/terzi
  • In Evidenza
  • Area riservata

IMPORTANT PUBLICATIONS AND REPORTS


IMPORTANT REPORT

The assessment of the degree of fragility and the need for continuous care of over sixty-four elders in the Lazio region.
Department of Biomedicine and Prevention, University of Rome Tor Vergata - IPASVI
 
The aging of the population leads to a change in demand for services, underlining the need for new patterns of intervention in the area and new access routes to welfare benefits. The current fragmentation of healthcare in many services directed to a few people, and often at a low intensity, is due to the lack of clear criteria for access to the services and standardized and homogenous operating procedures. The growing interest, of the last few decades, around the definition of individual fragility, makes this parameter a key for understanding assistance demand, to be combined with a proactive approach to dimensioning demand and identifying people at risk of negative outcomes such as death, or institutionalization. Early detection of fragility by means of multidimensional rapid-use evaluation tools used in routine screening activity may allow resetting regional social policies by focusing on a preventive approach... download the complete report

IMPORTANT PAPERS

Picture

The research to fight myelodysplastic syndromes

Rome - 16 November 2020

Dear colleagues,

It is a pleasure announce that Prof. Voso Maria Teresa et al. has published an innovative paper on the prestigious journal "Nature Medicine":

"Implications of TP53 allelic state for genome stability, clinical presentation and outcomes in myelodysplastic syndromes"


LINK.
nature_medicine.pdf
File Size: 11036 kb
File Type: pdf
Download File


Picture

The research to defeat leukemia is going on at the Department of Biomedicine and Prevention

Rome - 10 April 2020

Dear colleagues,

Here two paper with Prof. Adriano Venditti as PI regarding a research conducted from International Experts against Leukemia.


Acute myeloid leukemia Should persons with acute myeloid leukemia (AML) in 1st histological complete remission who are measurable residual disease (MRD) test positive receive an allotransplant?
published on the scientific journal "Leukemia"



GIMEMA AML1310 trial of risk-adapted, MRD-directed therapy for young adults with newly diagnosed acute myeloid leukemia.
published on the scientific journal "Blood"
perspective_leukemia_2020.pdf
File Size: 281 kb
File Type: pdf
Download File

gimema_aml13101.pdf
File Size: 1274 kb
File Type: pdf
Download File


Innocenzi E., De Domenico E., Ciccarone F., Zampieri M., Rossi G., Cicconi R., Bernardini R., Mattei M. and Grimaldi P.  (2019). "Paternal activation of CB2 cannabinoid receptor impairs placental and embryonic growth via an epigenetic mechanism". Scientific Reports volume 9, Article number: 17034.

​
Abstract
The cannabinoid receptor type 2 (CB2) is the peripheral receptor for cannabinoids, involved in the homeostatic control of several physiological functions. Male mitotic germ cells express a high level of CB2, whose activation promotes their differentiation in both in vitro and in vivo experiments, controlling the correct progression of spermatogenesis. However, it remains elusive if CB2 activation in spermatogonia could affect reproductive success in terms of fertility and healthy pregnancy outcomes. In this study, we explored the effects of male CB2 activation on sperm number and quality and its influence on next generation health. We show that exposure of male mice to JWH-133, a selective CB2 agonist, decreased sperm count, impaired placental development and reduced offspring growth. These defects were associated with altered DNA methylation/hydroxymethylation levels at imprinted genes in sperm and conserved in placenta. Our findings reveal that paternal selective activation of CB2 alters the sperm epigenome and compromises offspring growth. This study demonstrates, for the first time, a new role of CB2 signaling in male gametes in causing epigenetic alterations that can be transmitted to the next generation by sperm, highlighting potential risks induced by recreational cannabinoid exposure.

Orecchini E, Doria M, Antonioni A, Galardi S, Ciafrè SA, Frassinelli L, Mancone C, Montaldo C, Tripodi M, Michienzi A. ADAR1 restricts LINE-1 retrotransposition. Nucleic Acids Res. 2016 Sep 21. pii: gkw834

​
Abstract
​
Adenosine deaminases acting on RNA (ADARs) are involved in RNA editing that converts adenosines to inosines in double-stranded RNAs. ADAR1 was demonstrated to be functional on different viruses exerting either antiviral or proviral effects. Concerning HIV-1, several studies showed that ADAR1 favors viral replication. The aim of this study was to investigate the composition of the ADAR1 ribonucleoprotein complex during HIV-1 expression. By using a dual-tag affinity purification procedure in cells expressing HIV-1 followed by mass spectrometry analysis, we identified 14 non-ribosomal ADAR1-interacting proteins, most of which are novel. A significant fraction of these proteins were previously demonstrated to be associated to the Long INterspersed Element 1 (LINE1 or L1) ribonucleoparticles and to regulate the life cycle of L1 retrotransposons that continuously re-enter host-genome.Hence, we investigated the function of ADAR1 in the regulation of L1 activity.By using different cell-culture based retrotransposition assays in HeLa cells, we demonstrated a novel function of ADAR1 as suppressor of L1 retrotransposition. Apparently, this inhibitory mechanism does not occur through ADAR1 editing activity. Furthermore, we showed that ADAR1 binds the basal L1 RNP complex. Overall, these data support the role of ADAR1 as regulator of L1 life cycle.

Fairchild, G et al. Mapping the structural organization of the brain in conduct disorder: replication of findings in two independent samples.Journal of Child Psychology and Psychiatry; 14/06/2016; doi:10.1111/jcpp.12581
​
​
​
Abstract
BACKGROUND:Neuroimaging methods that allow researchers to investigate structural covariance between brain regions are increasingly being used to study psychiatric disorders. Structural covariance analyses are particularly well suited for studying disorders with putative neurodevelopmental origins as they appear sensitive to changes in the synchronized maturation of different brain regions. We assessed interregional correlations in cortical thickness as a measure of structural covariance, and applied this method to investigate the coordinated development of different brain regions in conduct disorder (CD). We also assessed whether structural covariance measures could differentiate between the childhood-onset (CO-CD) and adolescence-onset (AO-CD) subtypes of CD, which may differ in terms of etiology and adult outcomes.

METHODS:We examined interregional correlations in cortical thickness in male youths with CO-CD or AO-CD relative to healthy controls (HCs) in two independent datasets. The age range in the Cambridge sample was 16-21 years (mean: 18.0), whereas the age range of the Southampton sample was 13-18 years (mean: 16.7). We used FreeSurfer to perform segmentations and applied structural covariance methods to the resulting parcellations.

RESULTS:In both samples, CO-CD participants displayed a strikingly higher number of significant cross-cortical correlations compared to HC or AO-CD participants, whereas AO-CD participants presented fewer significant correlations than HCs. Group differences in the strength of the interregional correlations were observed in both samples, and each set of results remained significant when controlling for IQ and comorbid attention-deficit/hyperactivity disorder symptoms.

CONCLUSIONS:This study provides new evidence for quantitative differences in structural brain organization between the CO-CD and AO-CD subtypes, and supports the hypothesis that both subtypes of CD have neurodevelopmental origins.
​Dipartimento di Biomedicina e Prevenzione
Università di Roma Tor Vergata 

presso Facoltà di Medicina e Chirurgia
Indirizzo:  Viale Montpellier, 1 – Roma
Direttore del Dipartimento
Prof. Antonio De Lorenzo


Responsabile Amministrativo
Avv. Ombretta Picchioni


Content manager del sito
Prof. Andrea Malizia
  • Homepage
  • Department
    • Organization and Governance
    • Staff
  • Research
  • Didactic
    • Specialization School in Nutrition Science Università Cattolica Nostra Signora del Buon Consiglio
    • Scuola di Specializzazione in Scienza dell' Alimentazione
    • Scuola di Specializzazione di Igiene e Medicina Preventiva
    • Scuola di Specializzazione in Radioterapia
    • Scuola di Specializzazione di Radiodiagnostica
    • Scuola di Specializzazione in Ematologia
    • Medical genetics Graduated School
    • master_II_Level_Cytogenetics
    • master_II_Level_CBRNE
    • master_I_Level_PH. E. SOUCHARD
    • master_I_Level_CBRNE
    • master_I_Level_Nursing_Managment
    • master_I_Level_Critical_Nursing
    • master_I_Level_Stomaterapia
    • Corso_professionale_Nursery_midwifery_operating_room
  • Third Mission
    • Conventions
    • Laboratory of Environmental Microbiology
    • Environmental Chemistry Laboratory
    • ICP-Massa Laboratory
    • Laboratory of Forensic Genetics
    • Laboratory of Industrial Hygiene
    • Laboratory of Medical Genetics
    • Laboratory of Oncohematology
    • Section of Histology and Embryology-Laboratories of Reproductive and Developmental Biology
    • Section of Legal Medicine
    • Section of of Clinical Nutrition and Nutrigenomics
    • Simulation and Optimization Laboratory of National Health Service (SSN) Services
    • Laboratory for Primordial Cell Germ Study en
    • Laboratory for the Prevention and Management of Psychosocial Risks (stress, mobbing and burn out)
    • Laboratory of Environmental and Occupational Toxicology
    • Laboratorio of Human Anatomy
  • SUA-RD_en
    • Report on Research Planning 2014-2015
    • Research Report
    • Papers on SCOPUS
    • Statistics and Metrics
    • Research lines
  • Positions and Announcements
    • Positions
    • Commitments to third parties
  • In Evidence
  • News_en
  • Home
  • Dipartimento
    • Organizzazione e Governance
    • Personale
  • Ricerca
    • Dottorati di ricerca
  • Didattica
    • Scuola di Specializzazione in Scienze dell'Alimentazione (Università Cattolica Nostra Signora del Buon Consiglio)
    • Scuola di Specializzazione in Scienza dell' Alimentazione
    • Scuola di Specializzazione di Igiene e Medicina Preventiva >
      • LIBRETTO SCUOLA SPECIALIZZAZIONE
    • Scuola di Specializzazione in Radioterapia
    • Scuola di Specializzazione di Radiodiagnostica
    • Scuola di Specializzazione in Ematologia
    • Scuola di Specializzazione in Genetica Medica
    • master_II_Livello_Citogenetica
    • master_II_Livello_CBRNE
    • master_I_Livello_PH. E. SOUCHARD
    • master_I_Livello_CBRNE
    • master_I_Livello_Nursing_Managment
    • master_I_Livello_Critical_Nursing
    • master_I_Livello_Stomaterapia
    • Corso_professionale_Infermiere_Ostetrica_sala_operatoria
  • Terza Missione
    • Convenzioni
    • Laboratorio di Microbiologia Ambientale
    • Laboratorio di Chimica Ambientale
    • Laboratorio ICP-Massa
    • Laboratorio di Genetica Forense
    • Laboratorio di Genetica Medica
    • Sezione di Medicina Legale
    • Laboratorio di Oncoematologia
    • Laboratorio di Igiene Industriale
    • Laboratory for Primordial Cell Germ Study
    • Laboratorio dei Rischi Psicosociali
    • Sezione di Istologia ed Embriologia - Laboratorio di Biologia della Riproduzione e dello Sviluppo
    • Laboratorio di Simulazione - SSN
    • Laboratorio di Tossicologia Ambientale ed Occupazionale
    • Laboratori Sezione di Biologia
    • Laboratory of Human Anatomy
    • Sezione di Nutrizione clinica e Nutrigenomica
  • SUA-RD
    • Relazione Ricerca
    • Relazione Programmazione Ricerca
    • Elenco Pubblicazioni Scopus
    • Statistiche e Metriche
    • Linee di Ricerca
  • News
  • Bandi e Concorsi
    • Concorsi
    • Affidamento incarichi c/terzi
  • In Evidenza
  • Area riservata