Department of Biomedicine and Prevention
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Laboratory of Oncohematology

(Responsible: Prof. Maria Teresa Voso)

PRESENTATION OF THE LABORATORY

The laboratory of Oncohematology of the Department of Biomedicine and Prevention, directed by Prof.ssa Maria Teresa Voso, founded by Prof. Francesco Lo Coco, has more than 20-year experience in the genetic and molecular characterization of myeloid neoplasms and is a regional and national reference and counseling center for the diagnosis of acute myeloid leukemia, chronic myeloproliferative disorders and myelodysplastic syndromes. This activity is crucial for the correct prognostic assessment and risk-stratification of myeloid diseases, to better direct therapy and evaluate treatment response.
As a research center, the lab focuses on the identification of novel molecular alterations in myeloid diseases and on their correlation with clinical and prognostic information. The identification of biomarkers in hematologic neoplasms is a major challenge, as it can provide prognostic information for patient risk stratification, which is important to modulate treatment intensity (chemotherapy, stem cell transplantation, targeted treatments etc.), and help to identify actionable therapeutic targets for the development of new drugs. The research group has conducted pioneering studies in the field of minimal residual disease in acute myeloid leukemia, demonstrating the prognostic significance of molecular evaluation in predicting response to therapy and disease relapse.
In the national contest, the laboratory is one of the coordinating center of Gruppo Romano-Laziale Sindromi Mielodisplastiche (GROM-L) as well as of LabNet, a network of Italian hematology laboratories created within the GIMEMA group (the Italian cooperative group of adult hematological diseases), to foster the standardization of molecular diagnosis in acute myeloid leukemia, myelodysplastic syndromes, and myeloproliferative neoplasms. ( LabNet AML –Acute Myeloid Leukemia; JakNet –chronic myeloproliferative neoplasms Philadelphia-negative;  LabNet MDS –  Myelodisplastic Syndrome). The Lab also centralizes samples of several AML and MDS protocols for diagnostic and translational purposes.
All the necessary equipments are available in the Lab, and the staff is highly specialized in the study of the biology and pathogenesis of acute myeloid leukemia, particularly acute promielocytic leukemia, for which it is an internationally recognized center of excellence. Another focus of the research group are genetic and epigenetic alterations in myelodysplastic syndromes, de novo and therapy-related.

 
DIAGNOSTIC TESTS

• Cytogenetic analysis (conventional Karyotype)
• Molecular cytogenetics (FISH)
• Analysis of molecular alterations (PCR, RT-PCR, Q-RT-PCR, Dd-PCR, Sanger sequencing, NGS)
 
The proposed comprehensive diagnostic approach helps to properly define the specific subtypes of myeloid neoplasms, and is completed by the integration with clinical data. This helps to identify molecular targets at diagnosis and during follow-up through minimal residual assessments, with the final objective of a personalized medicine approach.

 
BASIC PANEL: mutations and recurrent translocations

• Karyotyping/FISH
• PML/RARA (bcr1-2-3)
• BCR/ABL1 (p190-p210-p230)
• RUNX1/RUNX1T1
• CBFb/MYH11
• DEK/NUP214
• FLT3-ITD-D835 and I836
• NPM1
• IDH1/IDH2
• c-KIT
• JAK2
• CALR
• MPL
• E2A/PBX1
• KMT2A/AFF1
• TEL/AML1
• SIL/TAL-1
• FIP1L1/PDGFRα
 
 
Advanced NGS  panel
ABL, ASXL1, BRAF, CALR, CBL, CEBPA, CSF3R, DNMT3A, ETV6, EZH2, FLT3, HRAS, IDH1, IDH2, JAK2, KIT, KRAS, MPL, NPM1, NRAS, PTPN11, RUNX1, SETBP1, SF3B1, SRSF2, TET2, TP53, U2AF1, WT1, ZRSR2
 
TEACHING ACTIVITY
The laboratory is responsible for the tutoring of students of the Faculty of Medicine and Surgery, the degree programs in Biomedical Laboratory Techniques, Medical Biotechnology, the specialty board in Hematology, and PhD programs. Teaching and training include the participation to courses, seminars and conferences, both internal, national and international. Foreign students are regularly hosted in the lab, in the context of scientific and cultural exchange programs with other European and non-European Universities and Research Centers.
Prof. M.T. Voso is Coordinator of the PhD course in Immunology, Molecular Medicine and Applied Biotechnology at the University of Rome Tor Vergata
 
MAIN LINES OF RESEARCH:
The group coordinates the molecular tests in the following projects and clinical protocols:
  1. GIMEMA AML1310 study (EudraCT number 2010-023809-36): "Risk-adapted, MRD-directed therapy for young adults with newly diagnosed acute myeloid leukemia" with conventional chemotherapy according to the schedule "3+7", and monitored on the response of the minimum residual disease assessed by multiparameter flow cytometry”. For this protocol, the Lab performed the centralized genetic analysis for all Italian centers, which was mandatory for protocol enrolment.
  2. AML1819 “Phase 3 Study to Assess Gemtuzumab, in Combination With Standard Chemotherapy, on MRD Levels, and the Role of Glasdegib as a Post-transplant Maintenance, in Adult, 18-60 Years, With Previously Untreated de Novo Fav-interm Risk AML”
  3. AML1919 “Phase 3, Prospective, Randomized Multi-center Intervention Trial of Early Intensification in AML Patients Bearing FLT3 Mutations Based on Peripheral Blast Clearance: A MYNERVA-GIMEMA Study“
  4. Healthcare Alliance for Resourceful Medicines Offensive against Neoplasms in Hematology (HARMONY) Grant Agreement number: 116026— HARMONY H2020-JTI-1M12-2015-06 (KOL for AML: MT Voso)
  5. TUD- APOLLO 064 “Study for Patients With Newly Diagnosed, High-risk Acute Promyelocytic Leukemia“
  6. “Role of somatic mutations and of the activation of inflammatory pathways in the pathogenesis of lower-risk MDS” NA-CL-MDS-PI-13673 (PI: M.T. Voso; Collaborators: E. Fabiani, G. Falconi)
  7. Project Title: GR-2018-12365529 Monitoring of therapy-resistant Leukemic Stem Cells and regulatory T-cells in refractory Acute Myeloid Leukemia and Acute Promyelocytic Leukemia (PI. Ottone Tiziana; U2. Laura Cicconi)
  8. “Personalized medicine program on myeloid neoplasms: characterization of the patient's genome for clinical decision making and systematic collection of real world data to improve quality of health care”
  9. progetto Ricerca Finalizzata Codice NET-2018-12365935 . (PI: M.T. Voso; Deputy PI: S. Lavorgna)
  10. AIRC 5x1000 Metastatic disease: the key unmet need in oncology: Title: Actionable targets in clonal progression and systemic spreading of myeloid neoplasms (MYNERVA). reference code 21267 (Rome GL/PI: M.T. Voso; Deputy PI:T. Ottone)
  11. Prospective randomized study on the feasibility of allogeneic stem cell transplantation in higher-riskmyelodysplastic syndromes, performed upfront or preceded by azacitidine or conventional chemotherapy, according to the BM-blast proportion (ACROBAT trial) Winner of the “Bando AIFA 2017 per la Ricerca Indipendente sui farmaci” Study Coordinator: MT Voso.
Research Funding Support
Picture

Staff

Sara Ceccolini, Fellow
Antonio Cristiano, Fellow
Emiliano Fabiani, PhD
Giulia Falconi, PhD
Elisa Galossi, Fellow
Hajro Hajrullaj, PhD Student
Annamaria Nardozza, Fellow
Nelida Ines Noguera, PhD
Dr.ssa Carmen Puzzangara, PhD Student
Dr.ssa Tiziana Ottone, PhD
Dr.ssa Serena Travaglini, PhD

Address

Laboratory of Oncohematology

Department of Biomedicine and Prevention
Faculty of Medicine and Surgery
University of Rome Tor Vergata

Building E North Second Floor

Via Montpellier ,1
00133 Rome, Italy
​
Tel +39 0672596281-6278-6280
​Dipartimento di Biomedicina e Prevenzione
Università di Roma Tor Vergata 

presso Facoltà di Medicina e Chirurgia
Indirizzo:  Viale Montpellier, 1 – Roma
Direttore del Dipartimento
Prof. Antonio De Lorenzo


Responsabile Amministrativo
Avv. Ombretta Picchioni


Content manager del sito
Prof. Andrea Malizia
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