RESEARCHER

e-mail: alessandro.michienzi@uniroma2.it
Telefono: +39 06 7259 6054
SSD: BIO/13
SC: 05/F1
Macro-area:
Biologia applicata
Campi di interesse: 
- RNA editing
- HIV-1 replication
- Nucleolus

 Dr. Alessandro Michienzi

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CURRICULUM VITAE

​1993 Degree (laurea) in Biological Science (summa cum laude): University of Rome “La Sapienza”.
                              
1993-1995           Post-graduate training: Centro Acidi Nucleici C.N.R c/o Department of Genetics and Molecular Biology in the Prof. Irene 

1995-1997       Fellowship from the Pasteur Institute-Cenci Bolognetti
 Foundation at the Department of Genetics and Molecular 
                                             Biology c/o Centro Acidi Nucleici C.N.R at the University of Rome “La Sapienza” 
1997-1998       A.I.D.S italian fellowship from the Istituto Superiore di Sanita’ at  
 the Department of Genetics and Molecular Biology c/o Centro
 Acidi Nucleici C.N.R at the University of Rome “La Sapienza” 
 
1998-2003            Post-doctoral fellow at the Beckman Institute c/o City of Hope,
 National Medical Center in the Prof. J. J. Rossi’s laboratory.

2003-2006           Postdoctoral research associate, Department Cellular Biology  and Neuroscience, I.S.S., Rome, Italy. Work in the laboratory of Dr. Sandra Gessani.

2006-Visiting Scientist at Beckman Institute-City of Hope Medical Centre Duarte, California, USA
 
Awards

 - Fondazione Cenci-Bolognetti Award Istituto Pasteur (1994)
-  Fellowship Fondazione Cenci-Bolognetti Istituto Pasteur (1995-1997)
-  Fellowship AIDS Research (Istituto Superiore di Sanità) 1997
-  Fondazione Aviralia Award 2011.

Selected papers

• RNA Editing in Interferonopathies.
  Frassinelli L, Galardi S, Ciafrè SA, Michienzi A.
  Methods Mol Biol. 2021;2181:269-286. doi: 10.1007/978-1-0716-0787-9_16.

• Post-transcriptional regulation of LINE-1 retrotransposition by AID/APOBEC and ADAR deaminases            Orecchini E, Frassinelli L, Galardi S, Ciafrè SA, Michienzi A                                                                           Chromosome Res. 2018 Mar;26(1-2):45-59. doi: 10.1007/s10577-018-9572-5.

• Restricting retrotransposons: ADAR1 is another guardian of the human genome.
  

        Orecchini E, Frassinelli L, Michienzi A.
        RNA Biol. 2017 Nov 2;14(11):1485-1491. doi: 10.1080/15476286.2017.1341033
​

• Resetting cancer stem cell regulatory nodes upon MYC inhibition.

Galardi S, Savino M, Scagnoli F, Pellegatta S, Pisati F, Zambelli F, Illi B, Annibali D, Beji S, Orecchini E, Alberelli MA, Apicella C, Fontanella RA, Michienzi A, Finocchiaro G, Farace MG, Pavesi G, Ciafrè SA, Nasi S.
EMBO Rep. 2016 Dec;17(12):1872-1889.

• ADAR1 restricts LINE-1 retrotransposition.

Orecchini E, Doria M, Antonioni A, Galardi S, Ciafrè SA, Frassinelli L, Mancone C, Montaldo C, Tripodi M, Michienzi A.
Nucleic Acids Res. 2016 Sep 21. pii: gkw834.

• The ADAR1 editing enzyme is encapsidated into HIV-1 virions.

Orecchini E, Federico M, Doria M, Arenaccio C, Giuliani E, Ciafrè SA, Michienzi A.
Virology. 2015 Nov;485:475-80.

• HIV-1 infection causes a down-regulation of genes involved in ribosome biogenesis.

Kleinman CL, Doria M, Orecchini E, Giuliani E, Galardi S, De Jay N, Michienzi A.
PLoS One. 2014 Dec 2;9(12):e113908.

• Editing of HIV-1 RNA by the double-stranded RNA deaminase ADAR1 stimulates viral infection.

Doria M, Neri F, Gallo A, Farace MG, Michienzi A.
Nucleic Acids Res. 2009 Sep;37(17):5848-58.

• CC chemokine ligand 2 down-modulation by selected Toll-like receptor agonist combinations contributes to T helper 1 polarization in human dendritic cells.

Del Cornò M, Michienzi A, Masotti A, Da Sacco L, Bottazzo GF, Belardelli F, Gessani S.
Blood. 2009 Jul 23;114(4):796-806
.