Research lines

RESEARCH LINES active following the ERC classification

Medicine and regenerative surgery

Sector

Research description

LS7

Evaluation of the role of growth factors in the autologous adipose tissue graft.
Evaluation of the role of stromal vascular fraction cells (SVF) of adipose tissue in the process of adipose tissue graft.
Evaluation of the role of insulin in the differentiation of adipose-derived stem cells (ASC).
Evaluation of the stability of the autologous adipose tissue graft through radiological follow-up.

Modelling for:

Infectious diseases (HIV, TB, Malaria e altro)

Sector

Research description

LS7

Predictive epidemiological, virological, genetic and molecular elements of HIV-1 genotypic drug resistance in sub - Saharan Africa, in a cohort of patients in the first antiretroviral therapeutic line in the DREAM program. Investigation and development of a model for the definition of the failure risk and optimization of the timing for the transition to the second line.
Impact of TDF-EFV based regimen on the growth of babies breastfed by mothers undergoing this regime during pregnancy and lactation for their health or just for the prevention of vertical transmission
Kobuvirus: new viral agents of gastroenteritis.
Cost/effectiveness modeling of treatments and universal testing in Sub-Saharan Africa.
MIRNA profile in HIV + slow progressor/elite controller vs. fast progressor and effects of therapy combined with antiviral.

Non infectious diseases

Sector

Research description

LS3

Microgravity effects on gene expression of germ cells.
The CD44 during the ripening of the cumulus oophorus.
Characterization of expression and function of protein STRA8 in the differentiation and beginning of meiosis of germ mammalian cells.
Gene expression control in spermatogenesis.
Paracrine control mechanisms of spermatogenesis in mammals.
Molecular control mechanisms of the beginning of meiosis.
In vitro production of germ cells from stem cells.
Role of ERK1/2 kinases in the development of primordial germ cells.
Role of MAP kinases in the development of primordial mouse germ cells.
In vivo study of the role of Spo11 gene splicing isoforms in the chromosomal segregation of sex chromosomes.
In vivo study of the role of H2AX histone in the meiotic progression of male germ cells.
Study of chromosomal dynamics and crossing-over formation in the presence of a reduced expression of the Spo11 gene.

LS4	Diabetes and atherosclerosis.

LS7

Morphological alterations in child celiac disease.
ASDBI: Standardization of the Italian Version of a New Instrument to Measure Autism Spectrum Disorders.
Impact of endometriosis on ovarian reserve markers.
Inflammation and atherosclerosis.
Sympathetic innervation of the renal artery in subjects undergoing dialysis and hypertensive.
Medullary histological modifications in the sickle-cell disease.
Muscular histological modifications in arthropathies.

...	Guardian Angel - Therapeutic adherence of patients with severe osteoporosis. Cancer-related fatigue.

Neurological disorders and imaging

Sector

Research description

LS2	HERVs expression in autism: a follow-up study

LS3	Characterization of microRNA modulation in neural stem cells derived from spinal cord in a murine model of spinal muscular atrophy.

LS5

Advanced Neuromonitoring: Data, Algorithms, and Clinical Inference
Burden of disease in tuberous sclerosis with neurological manifestations
Cognitive decline, dementia, stroke and bleeding risk: how can we improve the risk stratification in patients with atrial fibrillation
Early alterations in resting-state functional conectivity in HIV patients
Modelling uncertainty in non-invasive brain stimulation: a massively parallel Monte Carlo simulation approach
Non-gaussian diffusion imaging of neurodegenerative disorders
Regolazione dello splicing di SMN2 nella atrofia muscolare spinale (SMA)
Time-variant and nonlinear dynamics techniques applied to combined EEG/EKG analysis: novel investigative and diagnostic tools in epilepsy and neuromediated syncope

...

RM and DWI characteristics of the triple negative breast cancer.
Functional Radioisotopic Imaging in Oncology, Neurology and phlogosis/Inflammations.
Clinical impact of breast MRI in relation to various breast cancer treatments (RT, NCHT, RT-NCHT, no treatment).
Need for close follow-up in lesions BIRADS 3 in breast MRI and correlation with 2D and 3D sequences in endometriosis.
Role of MRI with morphological, kinetic, and DWI sequences in the evaluation of the junctional line in the uterus, in adenomyosis and its influence on uterine contractility.
The role of perfusion CT in the distinction between honeycombing and its "mimes".
Study of adipose tissue in obese patients with Chronic Renal Impairment through MRI Spectroscopy, as a predictive index of cardiovascular events.
Early assessment of the response to chemotherapy of liver metastases by diffusion MRI.
Evaluation by MRI of the increase in vascularization in breast treated with lipofilling associated with PRP

Organization of services

Sector

Research description

LS7

Cost/effectiveness analysis of denervation compared to medical therapy.
Senior citizens and demand for extra-hospital care. Assessment of healthcare demand in Lazio through an investigation of approximately 2000 senior residents in different municipalities in the region with the assistance of the local healthcare company (ASL) of residence and basic doctors.
Comparison of different models of AIDS cure in Africa based on the cost of the offered services and the outcomes observed.
Core competence in nursing training.
Health Education and Prevention.
Workplace as a health promotion factor: Link between Europe and Latin America
Impact of innovative organizational models on adherence to antiretroviral therapy in HIV positive patients in Sub-Saharan Africa. Assessment of the impact of organizational models based on the use of expert clients and mobile units on adherence to the treatment of patients resident in rural Sub-Saharan Africa.
The impact of the "Link for the Citizen" activated by the National Nursing Federation IPASVI in collaboration with the Ministry of Health.
Management models of complexity in medicine.
Organizational Health of Nurses.
Technological prices and appropriateness of linear cuts.

Interactions with the environment

Sector

Research description

LS6	Analysis of cobalt-specific HLA-DR restricted T-cell response in cobalt-allergic dermatitis

LS7	Microbial contamination of the air in dentistry determined by the tools for debridement. Microbiological contamination of the air in dentistry determined by the tools for debridement. Health effects of traditional and new generation chemical on workers.

LS8	The toxicity of nanomaterials engineered on follicular maturation.

Biomarkers and predictors of disease

Sector

Research description

LS4	Development of an evolved, low-cost technique for phenotyping and stratifying disease severity in COPD patients Machine-learning based prediction of intraoperative fluid responsiveness during major surgery

LS5

Identification of predictors for developmental trajectories and treatment effectiveness in Autism Spectrum Disorders
Retinal Nerve Fiber Layer Thickness as an endo-‐phenotype of Autism Spectrum Disorders and/or mental retardation
Brain complexity and multimodal machine-‐learning in Parkinson's Disease: a massively parallel computing approach to predicting cognitive and emotional drug response.

LS6

Identification of biological markers associated to predicting subjects developing active tuberculosis
Identification of relevant immunogenic proteins of Mycobacterium tuberculosis for diagnostic purpose
Il ruolo di PTX3 in gravidanza in condizioni infiammatorie
Profilo di espressione dei microRNA in diversi gruppi di pazienti positivi all'HIV: correlazioni prognostiche e di risposta al trattamento farmacologico

LS7

Biological and clinical prognostic factors in chronic lymphocytic leukemia, minimal residual disease and innovative therapies.
Prognostic factors in aggressive lymphomas.
Legionella's rapid identification with molecular methods.
Inhibin B levelsoncycleday 3 to predict the ovarian response to gonadotropin in women with PCOS.
TB and genomics of iron metabolism
Use of Engineered nanomaterials for biomedical use.
Validation of a screening model for TB in a HIV positive population.
Prognostic value of the minimal residual disease in acute myeloid leukemia.
Evaluation of anthropometric parameters and some laboratory parameters to verify the possible impact of drug therapies on the growth of newborns.

...

Identification of predictive and prognostic indexes for the definition of peripheral venous heritage.
Evaluation of the role of PET/CT in response to therapy with Pirfenidone, in patients with Idiopathic pulmonary fibrosis.
Comparison of Chest MRI and LDCT in pulmonary nodule screening: assessment of the sensitivity of the methods and cost/effectiveness ratio.

Genetics and epigenetics applied to aging, lifestyles and the environmen

Sector

Research description

LS2

Development of immuno-‐informatics systems for the identification of antigens at genomic level.
Pharmacogenetics.
Obesity and cardiovascular disease genetics.
Genetics of autoimmune diseases.
Gene-Nutrition Interaction: Nutrigenomics/nutrigenetics and personalized diets.
Nutrigenetics and personalized diets.
Nutrigenomics: personalized diets.
Genetic polymorphisms in adipose tissue and muscle cross talk.

LS6	Analysis of the interaction between HLA class I molecules and NK cell receptor involved in innate immunity

Rare Diseases, Innovation in Prevention and Treatment

Sector

Research description

LS7

Investigating new therapeutic approaches to Friedreich's Ataxia.
Phosphorylation of frataxin, the mitochondrial protein defective in Friedreich's ataxia, regulates its ubquitin/proteasome-dependent degradation.
RNA therapeutics for Friedreich’s Ataxia.
Development of a therapy for Friedreich’s Ataxia.

Tumors, new mechanisms of action

Sector

Research description

LS1	Alternative splicing adjustment in tumor progression.

LS2	Clusterin Foxp3 and Hepatocarcinoma. New metabolic genes in breast and colon carcinoma. Study of molecular mechanisms of resistance and chemotherapy sensitivity in testicular tumors.

LS3	Mechanism of action of chemotherapy drugs in inducing DNA damage and programmed death in mammalian oocytes.

LS4

Bio-molecular characterization of acute and chronic leukemia.
Characterization of the molecular and functional effects of Omomyc, a dominant negative of Myc, in tumorigenesis of glioblastoma: focus on microRNA and "tumor-initiating cells".
Molecular mechanisms involved in the acquisition of chemoresistance in pancreatic adenocarcinoma.
Pharmacological strategies to preserve the primordial follicle reserve in the ovary of cancer patients.
Research of early molecular events at the basis of the development of glioblastoma multiforme: analysis of transcriptome and proteome and comparison of patients with short and long survival.
Role of PI3K/mTOR signal pathway in the development of chemoresistance in neuroendocrine pancreatic tumors.
Study of the role of CLIC1 in modulation of microRNA expression in glioblastoma multiforme stem cells in relation to their tumorigenic capacity.

LS7

Hypomethylating agents in the acute myeloid leukemia of the elders.
Anti-Müllerian hormone follow-up in women treated by chemotherapy for lymphoma.
Long term skin toxicity and dose inhomogeneities effects after breast irradiation.
Minimal residual disease in acute myeloid leukemia.
Optimization of post-remission therapy in young patients suffering from acute myeloid leukemia.
Development in phase I studies of "small molecules" for the treatment of acute myeloid leukemia.
Acute myeloid leukemia treatment.
Use of lyophilized antibodies in the diagnosis and evaluation of the minimal residual disease in acute myeloid leukemia.

Other

Sector

Research description

LS2	COREA - Countermeasures for astronauts’ REActions. Nuclear fragmentation measures relevant to particle therapy

LS3	Development of an in vitro assay for the production of oocytes. SPO11 splicing regulation and its impact on human aneuploidy syndromes.

LS4

NACCP process setup.
Prevention, clinical and instrumental diagnosis and nutritional therapy of the various types of malnutrition (over and under) in all age groups and comorbidities: metabolic syndrome and its single components: insulin resistance, reduced glucose tolerance, diabetes, hypertension, dyslipidemias, hepatosteatosis; gout, sleep apnea syndrome.

LS6	Determination of conformational parameters determining B-cell epitopes.

LS7

In vivo dosimetry using synthetic single crystal diamonds.
The happiness of individuals and the existing relationships with health and physical activity.
Study of ceramic materials for biomedical applications.
Development of medical application tools for the FLUKA Monte Carlo code.
The use of misoprostol and estradiol before hysteroscopic surgery in postmenopausal women.
Total skin and Total body irradiation: new perspectives with new irradiation modalities.

LS..

From nursing students to health professionals: a longitudinal study on stress and burnout process starting from the university.
Dignity in the nursing profession.
Urinary incontinence in the boy and the young adult.
Urinary incontinence in the girl and the young adult.
Identification of the limitations of the ATS classification regarding the radiological diagnostic criteria of IPF.
Cinematography as a teaching method for Medical Humanities.
Educational models for promoting the self-care of the elderly person with particular attention to nutrition.
Nursing Minimum data set.