Department of Biomedicine and Prevention
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RESEARCH PLANNING REPORT 2014-2015


The joint mission of the biological, medical, surgical and public health disciplines of the Department of Biomedicine and Prevention is the study of new methods and prevention procedures through biomedical research and their effective implementation in the National Health Service (SSN). The Department also investigates new risk factors, biomarkers, models and techniques useful both for prevention and for the treatment of common and rare pathological conditions.
 
For this purpose, basic research has produced numerous in vitro and in vivo experimental models for the characterization of the processes that govern the stages of embryonic development. These studies have allowed the definition of some molecular processes to be used to control DNA methylation processes, cell cycle progression, and response to pharmacological treatments. In addition, models for in vitro screening of new molecules with potential pharmacological action have been produced.
Concerning infectious diseases, molecular mechanisms of HIV infection have been investigated and antiretroviral therapy evaluated to optimize the prevention of vertical transmission of HIV infection and for the prevention and control of maternal mortality through holistic intervention models.
Among the degenerative diseases studied, the main ones are the neurological and degenerative (atherosclerosis and diabetes). In particular, experimental models have been developed to characterize some of the molecules (frataxin) and genes (SMN) involved in Friedreich's ataxia and spinal muscular atrophy respectively.
Genetic studies have helped define the role of some genes in human diseases such as diabetes mellitus type 2 and spinal muscular atrophy.
Numerous anatomic-clinical studies, evaluating the expression of specific biomarkers related to the plaque vulnerability, have shown that organ damage to acute cerebrovascular syndromes is related to the thrombosis of a carotid plaque rather than the degree of stenosis of the vessel.
In the field of oncology, recent studies focused on identifying potential onset and/or disease progression biomarkers. In particular, some proteins involved in several stages of tumor progression (CLIC1-glioblastoma, FMRP-breast carcinoma, Clusterin-colorectal) have been characterized. In addition, some microRNAs were identified as tumor markers (miR-221/222; miR-128).
Numerous experimental studies introduced innovative therapies in diagnostic, medical and surgical fields. Of particular importance, a recent study has demonstrated the possibility of defeating Acute Promyelocytic Leukemia (APL) without chemotherapy.
The research of new imaging techniques combined with computational modeling and massive parallel calculation has allowed the development of non-invasive diagnostic methods for the diagnosis and characterization of microstructural alteration phenomena behind numerous neurodegenerative pathologies, as well as for the evaluation of pathologies of liver, breast, prostate, and for the quantification of the risk associated with repeated cranial trauma. In addition, the use of radio frequency models has allowed the development of protocols for percutaneous ablation of mammary and liver neoplasia.
Research in the field of Regenerative Medicine and Surgery has enabled the development of cutting-edge methods for the use of synthetic biomaterials, stem cells from adipose tissue and other tissues, and growth factors in platelets. In addition, mini-invasive surgery techniques were developed for both thoracic and vascular surgery to reduce risk in patients.
Particular attention is also given to the interaction with the environment. In this respect, interactions of particulate matter produced by new technologies (nanotechnologies) with the environment and with man have been studied. In addition, in order to facilitate in vivo reconstitution of damaged tissues, research on biocompatibility of synthetic materials has been conducted.
In the area of organization of services, it is worth mentioning a line of research that deals with adherence to therapy and prescriptions, health education and training of medical personnel through the analysis of the most appropriate pathways in Healthcare in order to reach the most rational use of scarce resources, and thus possible savings for hospitals and healthcare facilities.


Download the full report (in italian)
Summary of the Document
Abstract
Research Products
Research Report
1. Medicine and regenerative surgery
2. Modelling
3. Biomarkers and predictors of disease
4. Genetics and epigenetics applied to aging, lifestyles and the environment
5. Rare Diseases, Innovation in Prevention and Treatment
​Dipartimento di Biomedicina e Prevenzione
Università di Roma Tor Vergata 

presso Facoltà di Medicina e Chirurgia
Indirizzo:  Viale Montpellier, 1 – Roma
Direttore del Dipartimento
Prof. Antonio De Lorenzo


Responsabile Amministrativo
Avv. Ombretta Picchioni


Content manager del sito
Prof. Andrea Malizia
  • Homepage
  • Department
    • Organization and Governance
    • Staff
  • Research
  • Didactic
    • Specialization School in Nutrition Science Università Cattolica Nostra Signora del Buon Consiglio
    • Scuola di Specializzazione in Scienza dell' Alimentazione
    • Scuola di Specializzazione di Igiene e Medicina Preventiva
    • Scuola di Specializzazione in Radioterapia
    • Scuola di Specializzazione di Radiodiagnostica
    • Scuola di Specializzazione in Ematologia
    • Medical genetics Graduated School
    • master_II_Level_Cytogenetics
    • master_II_Level_CBRNE
    • master_I_Level_PH. E. SOUCHARD
    • master_I_Level_CBRNE
    • master_I_Level_Nursing_Managment
    • master_I_Level_Critical_Nursing
    • master_I_Level_Stomaterapia
    • Corso_professionale_Nursery_midwifery_operating_room
  • Third Mission
    • Conventions
    • Laboratory of Environmental Microbiology
    • Environmental Chemistry Laboratory
    • ICP-Massa Laboratory
    • Laboratory of Forensic Genetics
    • Laboratory of Industrial Hygiene
    • Laboratory of Medical Genetics
    • Laboratory of Oncohematology
    • Section of Histology and Embryology-Laboratories of Reproductive and Developmental Biology
    • Section of Legal Medicine
    • Section of of Clinical Nutrition and Nutrigenomics
    • Simulation and Optimization Laboratory of National Health Service (SSN) Services
    • Laboratory for Primordial Cell Germ Study en
    • Laboratory for the Prevention and Management of Psychosocial Risks (stress, mobbing and burn out)
    • Laboratory of Environmental and Occupational Toxicology
    • Laboratorio of Human Anatomy
  • SUA-RD_en
    • Report on Research Planning 2014-2015
    • Research Report
    • Papers on SCOPUS
    • Statistics and Metrics
    • Research lines
  • Positions and Announcements
    • Positions
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  • Home
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    • Organizzazione e Governance
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    • Scuola di Specializzazione in Scienze dell'Alimentazione (Università Cattolica Nostra Signora del Buon Consiglio)
    • Scuola di Specializzazione in Scienza dell' Alimentazione
    • Scuola di Specializzazione di Igiene e Medicina Preventiva >
      • LIBRETTO SCUOLA SPECIALIZZAZIONE
    • Scuola di Specializzazione in Radioterapia
    • Scuola di Specializzazione di Radiodiagnostica
    • Scuola di Specializzazione in Ematologia
    • Scuola di Specializzazione in Genetica Medica
    • master_II_Livello_Citogenetica
    • master_II_Livello_CBRNE
    • master_I_Livello_PH. E. SOUCHARD
    • master_I_Livello_CBRNE
    • master_I_Livello_Nursing_Managment
    • master_I_Livello_Critical_Nursing
    • master_I_Livello_Stomaterapia
    • Corso_professionale_Infermiere_Ostetrica_sala_operatoria
  • Terza Missione
    • Convenzioni
    • Laboratorio di Microbiologia Ambientale
    • Laboratorio di Chimica Ambientale
    • Laboratorio ICP-Massa
    • Laboratorio di Genetica Forense
    • Laboratorio di Genetica Medica
    • Sezione di Medicina Legale
    • Laboratorio di Oncoematologia
    • Laboratorio di Igiene Industriale
    • Laboratory for Primordial Cell Germ Study
    • Laboratorio dei Rischi Psicosociali
    • Sezione di Istologia ed Embriologia - Laboratorio di Biologia della Riproduzione e dello Sviluppo
    • Laboratorio di Simulazione - SSN
    • Laboratorio di Tossicologia Ambientale ed Occupazionale
    • Laboratori Sezione di Biologia
    • Laboratory of Human Anatomy
    • Sezione di Nutrizione clinica e Nutrigenomica
  • SUA-RD
    • Relazione Ricerca
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    • Elenco Pubblicazioni Scopus
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  • News
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  • In Evidenza
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